Intrauterine risk factors for precocious atherosclerosis.

Skilton MR

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Intrauterine risk factors for precocious atherosclerosis.

机译：宫内早熟性动脉粥样硬化的危险因素。

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Evidence from noninvasive ultrasound studies of the neonatal aorta and fetal and early childhood postmortem studies indicates that impaired fetal growth, in utero exposure to maternal hypercholesterolemia, and diabetic macrosomia may all be important risk factors for vascular changes consistent with the earliest physical signs of atherosclerosis. Although the exact mechanisms that underlie these associations remain unclear, animal models have suggested that the use of antioxidant, lipid-lowering, and other innovative therapies may counteract the impact of these intrauterine risk factors for cardiovascular disease. This review summarizes the current evidence for intrauterine factors that have a direct impact on atherosclerosis and provides potential treatment and prevention strategies.

机译：新生儿主动脉以及胎儿和儿童早期死后研究的非侵入性超声研究的证据表明，胎儿生长受损，子宫内暴露于母体高胆固醇血症和糖尿病大儿症可能都是与早期动脉粥样硬化的体征相一致的重要的血管变化危险因素。尽管仍不清楚这些关联的确切机制，但动物模型表明，抗氧化剂，降脂和其他创新疗法的使用可能抵消了这些宫内危险因素对心血管疾病的影响。这篇综述总结了直接影响动脉粥样硬化的宫内因素的当前证据，并提供了潜在的治疗和预防策略。

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《Pediatrics: Official Publication of the American Academy of Pediatrics》 |2008年第3期|共5页
作者
Skilton MR;
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正文语种 eng
中图分类儿科学;
关键词
Age of Onset; Atherosclerosis; Female; Fetal Growth Retardation; Fetal Macrosomia; 发病年龄; 动脉粥样硬化; 胎儿生长迟缓; 巨大胎儿; 高胆固醇血症; 发病率; 婴儿; 新生;

机译：Age of Onset;Atherosclerosis;Female;Fetal Growth Retardation;Fetal Macrosomia;发病年龄;动脉粥样硬化;胎儿生长迟缓;巨大胎儿;高胆固醇血症;发病率;婴儿;新生;

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1. Intrauterine risk factors for precocious atherosclerosis. [J] . Skilton MR Pediatrics: Official Publication of the American Academy of Pediatrics . 2008,第3期

机译：宫内早熟性动脉粥样硬化的危险因素。
2. Tissue factor pathway inhibitor, vascular risk factors and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. [J] . Mitchell CT, Kamineni A, Palmas Atherosclerosis . 2009,第1期

机译：组织因子途径抑制剂，血管危险因子和亚临床动脉粥样硬化：动脉粥样硬化的多民族研究。
3. Plasma hepatocyte growth factor and the relationship between risk factors and carotid atherosclerosis. [J] . Yamamoto Y, Kohara K, Tabara Y, Hypertension research: Official journal of the Japanese Society of Hypertension . 2002,第5期

机译：血浆肝细胞生长因子及其与危险因素与颈动脉粥样硬化的关系。
4. GC-MS/MS Characterization of EDCs in Human Tissues for Environmental Risk Factors Assessment in the Sudden Infant and Sudden Intrauterine Death Syndromes. [C] . Pierangela Palma, Veronica Termopoli, Giorgio Famiglini, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：突发婴儿环境风险因素评估的人体组织中EDC的GC-MS / MS表征，术后宫内死亡综合征。
5. Investigation of Arterial Geometry as a Local Risk Factor for Carotid Atherosclerosis. [D] . Bijari, Payam Bahman. 2013

机译：动脉几何作为颈动脉粥样硬化局部危险因素的研究。
6. Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis. [O] . A A Quyyumi, N Dakak, N P Andrews, 1995

机译：一氧化氮在人冠状动脉循环中的活性。危险因素对冠状动脉粥样硬化的影响。
7. Conventional and novel cardiovascular risk factors in young Finns and their associations with structural and functional vascular changes of subclinical atherosclerosis. The Cardiovascular Risk in Young Finns Study [O] . Raiko Juho 2011

机译：年轻芬兰人的常规和新型心血管危险因素及其与亚临床动脉粥样硬化的结构和功能性血管变化的关系。年轻芬兰人的心血管风险研究

Intrauterine risk factors for precocious atherosclerosis.

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