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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Behavior in early adolescence and risk of human papillomavirus infection as a young adult: results from a population-based study.
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Behavior in early adolescence and risk of human papillomavirus infection as a young adult: results from a population-based study.

机译：青春期初期的行为和年轻人乳头瘤病毒感染的风险：基于人群的研究结果。

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OBJECTIVE: The goal of this study was to determine the utility of a risk factor-based approach to human papillomavirus catch-up vaccination. METHODS: Data from waves I and III of the National Longitudinal Study of Adolescent Health were examined to determine the association between adolescent characteristics and future human papillomavirus infection. Analysis was restricted to 3181 female subjects who were >12 years of age when risk factors were assessed in wave I (1994-1995) and who underwent human papillomavirus testing as young adults in wave III (2001-2002). The main outcome of interest was a positive test result for >or=1 of 4 human papillomavirus types (human papillomavirus-6, -11, -16, or -18) targeted by the human papillomavirus vaccine currently available in the United States. Separate analyses were performed for sexually active and virginal adolescents. Poststratification sampling weights were used to generate nationally representative estimates. RESULTS: Although nearly one half (43%) of thefemale adolescents were sexually active in wave I, adolescent sexual activity status was not associated with future detection of vaccine-specific human papillomavirus infection. Furthermore, for both virginal and sexually active adolescents, none of the assessed risk factors was associated with increased odds of future vaccine-specific human papillomavirus infection in multivariate models. Similar results were obtained when all high-risk human papillomavirus types were assessed as the outcome measure. CONCLUSIONS: Behavioral risk factors assessed during adolescence are inadequate predictors of future infection with vaccine-type human papillomavirus. A risk factor-based approach to human papillomavirus catch-up vaccination is unlikely to be an effective implementation strategy.
机译：目的：本研究的目的是确定基于风险因子的方法对人乳头瘤病毒追赶疫苗的实用性。方法：检查了来自国家青少年健康纵向研究的第一和第三波的数据，以确定青少年特征与未来人类乳头瘤病毒感染之间的关联。在第一波（1994-1995年）中评估危险因素并在第三波（2001-2002年）中作为年轻人进行人乳头瘤病毒测试时，分析仅限于3181岁> 12岁的女性受试者。感兴趣的主要结果是目前在美国可获得的人类乳头瘤病毒疫苗靶向的4种人类乳头瘤病毒类型（人类乳头瘤病毒-6，-11，-16或-18）中的>或= 1的阳性测试结果。对性活跃和处女青少年分别进行了分析。后分层抽样权重用于生成全国代表性的估计值。结果：尽管近一半（43％）的女性青少年在第一波中有性活动，但青少年的性活动状态与未来检测疫苗特异性人乳头瘤病毒感染无关。此外，对于初生和性活跃的青少年，在多变量模型中，没有一个评估的危险因素与未来疫苗特异性人乳头瘤病毒感染的几率增加相关。当将所有高危型人乳头瘤病毒类型评估为结果指标时，可获得相似的结果。结论：在青春期评估的行为危险因素不能充分预测疫苗型人乳头瘤病毒未来感染的可能性。基于风险因素的人乳头瘤病毒追赶疫苗接种方法不太可能是有效的实施策略。

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