...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity.
【24h】

A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity.

机译：在促红细胞生成素中添加维生素B12和叶酸对早产贫血的治疗效果的随机对照试验。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Premature infants, especially those with birth weights of <1500 g, often suffer from anemia of prematurity and associated problems. Erythropoietin therapy is a safe effective way to prevent and to treat anemia of prematurity. We hypothesized that combined administration of vitamin B12 and folate with erythropoietin and iron would enhance erythropoietin-induced erythropoiesis. METHODS: In a randomized, controlled trial, 64 premature infants (birth weight: 801-1300 g) receiving erythropoietin and iron supplementation were assigned randomly to receive either vitamin B12 (3 microg/kg per day) and folate (100 microg/kg per day) (treatment group) or a lower dose of folate (60 microg/kg per day) (control group). RESULTS: During the 4-week observation period, vitamin B12 and folate enhanced erythropoietin-induced erythropoiesis significantly, as indicated by a 10% increase in red blood cell counts, compared with folate alone. Hemoglobin and hematocrit levels remained stable in the treatment group, whereas they decreased in the control group. Vitamin B12 levels in the treatment group increased over baseline and control values, whereas red blood cell folate levels were comparable between the groups. Subsequent analysis showed slight nonsignificant differences in baseline red blood cell count, hemoglobin level, hematocrit level, and mean corpuscular volume values, which must be addressed as a limitation. CONCLUSIONS: With the limitation of a slight imbalance in baseline data between the study groups, combined therapy with vitamin B12, folate, erythropoietin, and orally and intravenously administered iron seemed more effective in stimulating erythropoiesis among premature infants, compared with erythropoietin, iron, and low-dose folate alone. Additional trials are necessary to confirm these data.
机译：背景：早产婴儿，特别是出生体重<1500 g的婴儿，经常患有早产儿贫血和相关问题。促红细胞生成素疗法是预防和治疗早产儿贫血的安全有效方法。我们假设维生素B12和叶酸与促红细胞生成素和铁的联合给药会增强促红细胞生成素诱导的促红细胞生成。方法：在一项随机对照试验中，随机分配64名接受促红细胞生成素和铁补充的早产儿（出生体重：801-1300 g），分别接受维生素B12（每天3微克/千克）和叶酸（每次100微克/千克）。 （治疗组）或较低剂量的叶酸（每天60微克/千克）（对照组）。结果：在为期4周的观察期内，维生素B12和叶酸显着增强了促红细胞生成素诱导的促红细胞生成，与单独叶酸相比，红细胞计数增加了10％。血红蛋白和血细胞比容水平在治疗组中保持稳定，而在对照组中下降。治疗组中的维生素B12水平高于基线值和对照组值，而两组之间的红细胞叶酸水平相当。随后的分析显示，基线红细胞计数，血红蛋白水平，血细胞比容水平和平均红细胞体积值略有不显着差异，必须加以限制。结论：由于研究组之间基线数据略有不平衡的局限性，与促红细胞生成素，铁和三价铁相比，与维生素B12，叶酸，促红细胞生成素以及口服和静脉内施用铁联合治疗似乎更有效地刺激早产儿的促红细胞生成。单独服用低剂量的叶酸。必须进行其他试验才能确认这些数据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号