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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Iron deficiency anemia and cognitive function in infancy.
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Iron deficiency anemia and cognitive function in infancy.

机译：婴儿缺铁性贫血和认知功能。

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OBJECTIVES: This study examined effects of iron deficiency anemia (IDA) on specific domains of infant cognitive function and the role of IDA-related socioemotional deficits in mediating and/or moderating these effects. METHODS: Infants were recruited during routine 9-month visits to an inner-city clinic. IDA was defined as hemoglobin level <110 g/L with > or =2 abnormal iron deficiency indicators (mean corpuscular volume, red cell distribution width, zinc protoporphyrin, transferrin saturation, and ferritin). At 9 and 12 months, the Fagan Test of Infant Intelligence (FTII); A-not-B task; Emotionality, Activity, and Sociability Temperament Survey; and Behavior Rating Scale were administered. Analyses were adjusted for potential confounders, including age and sociodemographic variables. RESULTS: Twenty-eight infants met criteria for IDA, 28 had nonanemic iron deficiency (NA ID) and 21 had iron sufficiency (IS). There was a linear effect for object permanence at 9 months: infants with IDA were least likely to exhibit object permanence, IS most likely, and NA ID intermediate. Infants with IDA and those with hemoglobin level < or =105 g/L showed poorer recognition memory on the FTII than infants without IDA. The Behavior Rating Scale orientation/engagement measure partially mediated these effects. Stronger effects of IDA on these outcomes were seen in infants who scored more poorly on the socioemotional measures. CONCLUSIONS: These data indicate poorer object permanence and short-term memory encoding and/or retrieval in infants with IDA at 9 months. These cognitive effects were attributable, in part, to IDA-related deficits in socioemotional function. Children with poor socioemotional performance seem to be more vulnerable to the effects of IDA on cognitive function.
机译：目的：本研究检查了缺铁性贫血（IDA）对婴儿认知功能特定领域的影响以及IDA相关的社会情绪缺陷在介导和/或调节这些作用中的作用。方法：在常规的9个月内城内诊所就诊期间招募婴儿。 IDA被定义为血红蛋白水平<110 g / L，具有≥2个异常铁缺乏指标（平均红细胞体积，红细胞分布宽度，锌原卟啉，转铁蛋白饱和度和铁蛋白）。在9个月和12个月时，进行了Fagan婴儿智力测验（FTII）;非B任务;情绪，活动和社交性气质调查;并进行行为评定量表。对潜在混杂因素（包括年龄和社会人口统计学变量）进行了分析调整。结果：28例婴儿符合IDA标准，28例为非贫血铁缺乏症（NA ID），21例为铁充足（IS）。 9个月时对象持久性具有线性影响：IDA婴儿表现出对象持久性的可能性最小，IS最可能，NA ID中等。与没有IDA的婴儿相比，IDA的婴儿和血红蛋白水平≤105 g / L的婴儿对FTII的识别记忆力较差。行为评级量表的取向/参与度测量部分地介导了这些影响。在社会情感测验得分较差的婴儿中，IDA对这些结局的作用更强。结论：这些数据表明9个月的IDA婴儿的对象永久性较差，短期记忆编码和/或检索较差。这些认知作用部分归因于IDA相关的社会情感功能缺陷。社会情感表现较差的儿童似乎更容易受到IDA对认知功能的影响。

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