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首页> 外文期刊>Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies >Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation.
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Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation.

机译：小儿急性肺损伤中血浆可溶性细胞间黏附分子-1的早期升高确定了死亡风险增加和机械通气时间延长的患者。

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OBJECTIVE: To determine whether soluble intercellular adhesion molecule (sICAM)-1, a biological marker of alveolar epithelial and lung endothelial injury and alveolar macrophage activation, is elevated in the plasma of pediatric patients with acute lung injury and to examine whether elevated plasma sICAM-1 levels correlate with two clinically relevant outcomes, mortality and the duration of mechanical ventilation. DESIGN: Prospective cohort study. SETTING: Pediatric intensive care units at an urban children's hospital and a tertiary university medical center. PATIENTS: Eighty-three pediatric patients with acute lung injury and five intubated controls. INTERVENTIONS: Plasma sICAM-1 levels were measured on days 1 and 2 of acute lung injury in pediatric patients and on day 1 of mechanical ventilation in control patients. MEASUREMENTS AND MAIN RESULTS: Plasma sICAM-1 levels were significantly higher in patients with acute lung injury compared with controls (966 +/- 830 vs. 251 +/- 168 ng/mL, p <.05). Levels of sICAM-1 were also significantly higher on days 1 and 2 of acute lung injury in nonsurvivors and in patients requiring prolonged duration of mechanical ventilation. Also, plasma sICAM-1 levels >1000 ng/mL had a high specificity for identifying nonsurvivors of acute lung injury. CONCLUSIONS: Early elevation of sICAM-1 in the plasma of pediatric patients with acute lung injury is associated with increased risk of death or prolonged duration of mechanical ventilation.
机译：目的：确定儿童急性肺损伤患者血浆中可溶性细胞间粘附分子（sICAM）-1（肺泡上皮和肺内皮损伤以及肺泡巨噬细胞活化的生物学标志物）是否升高，并检查血浆sICAM- 1水平与两个临床相关结局，死亡率和机械通气持续时间相关。设计：前瞻性队列研究。地点：城市儿童医院和三级大学医疗中心的儿科重症监护室。患者：八十三例急性肺损伤的儿童患者和五个插管对照者。干预措施：在小儿患者急性肺损伤的第1天和第2天以及对照组患者在机械通气的第1天测量血浆sICAM-1水平。测量和主要结果：与对照组相比，急性肺损伤患者的血浆sICAM-1水平显着更高（966 +/- 830与251 +/- 168 ng / mL，p <.05）。在非幸存者和需要延长机械通气时间的患者中，急性肺损伤的第1天和第2天sICAM-1的水平也显着升高。而且，血浆sICAM-1水平> 1000 ng / mL对鉴定急性肺损伤的非幸存者具有很高的特异性。结论：患有急性肺损伤的小儿血浆中sICAM-1的早期升高与死亡风险增加或机械通气时间延长有关。

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