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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Early postnatal dexamethasone decreases hepatocyte growth factor in tracheal aspirate fluid from premature infants.
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Early postnatal dexamethasone decreases hepatocyte growth factor in tracheal aspirate fluid from premature infants.

机译：出生后早期地塞米松可降低早产儿气管抽吸液中的肝细胞生长因子。

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摘要

OBJECTIVE: To evaluate in preterm infants the effect of dexamethasone on hepatocyte growth factor (HGF), an epithelial cell mitogen, and on vascular endothelial growth factor (VEGF), an endothelial cell mitogen, in tracheal aspirate fluid (TAF). METHODS: Thirty preterm infants (birth weight: 1000-1500 g) with respiratory distress syndrome were randomized to receive dexamethasone or to serve as control subjects. Dexamethasone was started at the age of 12 to 24 hours at a dose of 0.5 mg/kg/d for 2 days and 0.25 mg/kg/d for the subsequent 2 days. HGF and VEGF levels were examined from TAF samples during the first postnatal week. For eliminating the effect of dilution, the concentration of the secretory component of immunoglobulin A was determined. Student t test, 1-way analysis of variance, chi2, and simple regression analysis were used for statistical analysis. RESULTS: Mean HGF concentrations were similar in the dexamethasone and control groups on days 1 to 2, but the dexamethasone group had a lower mean HGF concentration on days 3 to 4 and 5 to 7. In contrast, no differences existed in mean VEGF levels between the dexamethasone and control groups. CONCLUSIONS: In preterm infants who received early postnatal dexamethasone, reduced levels of HGF were seen in tracheal aspirates. This reduction may participate in the suppressive effects of dexamethasone on lung development.
机译：目的：评估早产儿地塞米松对气管抽吸液（TAF）中肝细胞生长因子（HGF）和上皮细胞有丝分裂原的影响。方法：将30名呼吸窘迫综合征的早产儿（出生体重：1000-1500 g）随机接受地塞米松治疗或作为对照组。地塞米松开始于12至24小时，剂量为0.5 mg / kg / d，持续2天，随后的0.25 mg / kg / d，持续2天。在产后第一周从TAF样本中检查HGF和VEGF水平。为了消除稀释的影响，测定了免疫球蛋白A的分泌成分的浓度。统计分析使用了学生t检验，方差的1-way分析，chi2和简单回归分析。结果：地塞米松和对照组在第1至2天的平均HGF浓度相似，但地塞米松组在第3至4和5至7天的平均HGF浓度较低。相反，两者之间的平均VEGF水平没有差异地塞米松和对照组。结论：在出生后早期接受地塞米松的早产儿中，气管吸出物中的HGF水平降低。这种减少可能参与了地塞米松对肺发育的抑制作用。

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