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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Eosinophilic hepatitis in an adolescent during lisdexamfetamine dimesylate treatment for ADHD.
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Eosinophilic hepatitis in an adolescent during lisdexamfetamine dimesylate treatment for ADHD.

机译：赖氨酸安非他明二甲磺酸酯治疗多动症期间青少年的嗜酸性肝炎。

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摘要

We describe here the case of an adolescent who developed eosinophilic hepatitis during treatment for attention-deficit/hyperactivity disorder with lisdexamfetamine dimesylate (Vyvanse [Shire US Inc, Wayne, PA]). A 14-year-old boy presented to his primary care provider with abdominal pain and worsening jaundice. A diagnosis of hepatitis was made with biochemical markers, but evaluation failed to provide an etiology. Worsening hepatitis prompted hospitalization and initiation of steroids for presumed autoimmune hepatitis. A subsequent liver biopsy showed evidence of eosinophilic hepatitis. Known causes of eosinophilic hepatitis were ruled out, and a presumptive diagnosis of reaction to lisdexamfetamine dimesylate was made. Discontinuation of the medication led to resolution of the hepatitis and normalization of the liver biopsy. To our knowledge, this is the first report of hepatic injury attributed to lisdexamfetamine dimesylate.
机译：我们在这里描述了一个青少年患者的情况，该患者在用赖氨糖胺二甲磺酸酯（Vyvanse [Shire US Inc，Wayne，PA]）治疗注意力不足/多动障碍期间出现了嗜酸性粒细胞性肝炎。一个14岁的男孩因腹痛和黄疸加重而出现在其初级保健提供者手中。用生化标记物诊断为肝炎，但评估未能提供病因。肝炎恶化使推测为自身免疫性肝炎的住院和类固醇治疗开始。随后的肝活检显示嗜酸性肝炎的证据。排除了嗜酸性粒细胞性肝炎的已知原因，并做出了对赖氨苯丙胺二甲磺酸酯反应的推测诊断。停药导致肝炎消退和肝活检正常化。据我们所知，这是首次归因于赖氨苯丙胺二甲磺酸盐引起的肝损伤。

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