...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies >Red blood cell transfusion in critically ill children: A narrative review
【24h】

Red blood cell transfusion in critically ill children: A narrative review

机译：危重儿童的红细胞输注：叙事回顾

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To review the pathophysiology of anemia, as well as transfusion-related complications and indications for red blood cell (RBC) transfusion, in critically ill children. Although allogeneic blood has become increasingly safer from infectious agents, mounting evidence indicates that RBC transfusions are associated with complications and unfavorable outcomes. As a result, there has been growing interest and efforts to limit RBC transfusion, and indications are being revisited and revamped. Although a so-called restrictive RBC transfusion strategy has been shown to improve morbidity and mortality in critically ill adults, there have been relatively few studies on RBC transfusion performed in critically ill children.Data Sources: Published literature on transfusion medicine and outcomes of RBC transfusion.Study Selection, Data Extraction, and Synthesis: After a brief overview of physiology of oxygen transportation, anemia compensation, and current transfusion guidelines based on available literature, risks and outcomes of transfusion in general and incritically ill children are summarized in conjunction with studies investigating the safety of restrictive transfusion strategies in this patient population.Conclusions: The available evidence does not support the extensive use of RBC transfusions in general or critically ill patients. Transfusions are still associated with risks, and although their benefits are established in limited situations, the associated negative outcomes in many more patients must be closely addressed. Given the frequency of anemia and its proven negative outcomes, transfusion decisions in the critically ill children should be based on individual patient's characteristics rather than generalized triggers, with consideration of potential risks and benefits, and available blood conservation strategies that can reduce transfusion needs.
机译：目的：回顾危重儿童贫血的病理生理学，以及与输血有关的并发症和红细胞（RBC）输注的适应症。尽管同种异体血液从感染源中变得越来越安全，但越来越多的证据表明，RBC输血与并发症和不良预后相关。结果，限制红细胞输注的兴趣和努力日益增长，适应症正在重新研究和改进。尽管已经显示出一种所谓的限制性RBC输注策略可以改善危重成年人的发病率和死亡率，但在危重儿童中进行RBC输注的研究相对较少。数据来源：有关输血医学和RBC输注结果的已发表文献研究选择，数据提取和综合：在根据现有文献对氧气输送的生理机制，贫血补偿和现行输血指南进行了简要概述之后，结合研究调查总结了普通和重症儿童的输血风险和结果结论：现有证据不支持在普通或重症患者中广泛使用RBC输血。输血仍与风险相关，尽管其益处仅在有限的情况下确立，但必须密切解决更多患者相关的不良后果。考虑到贫血的发生频率和已证实的阴性结果，危重病儿童的输血决策应基于个体患者的特征而不是普遍的诱因，并考虑潜在的风险和益处，并考虑可以减少输血需求的血液保存策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号