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首页> 外文期刊>Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies >Serial circulating vasopressin levels in children with septic shock.
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Serial circulating vasopressin levels in children with septic shock.

机译：小儿败血性休克的系列循环加压素水平。

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BACKGROUND: Septic shock is an important cause of death in pediatric intensive care units. Initial evaluations have shown that vasopressin may have a role in catecholamine refractory shock in adults. It is important to determine whether children with septic shock have deficiency of vasopressin. This will help in defining the role of vasopressin in septic shock. DESIGN: Prospective cohort study. SETTING: Pediatric intensive care unit of a tertiary care hospital in north India. PATIENTS: Patients were children with septic shock, and controls were children with sepsis but no shock. STUDY DESIGN: Vasopressin levels in plasma were determined by enzyme-linked immunosorbent assay for children with septic shock at diagnosis (baseline) and thereafter at 24, 48, and 96 hrs to determine the time trends. The baseline vasopressin values for children with septic shock were compared with those for children without shock. RESULTS: The median (95% confidence interval) vasopressin level at baseline in children with septic shock was 116 (63.3-130.7) pg/mL, and in children with sepsis but no shock it was 106 (61.7-131.77) pg/mL. The median value for survivors was 76 (44.6-130.9) pg/mL, and for nonsurvivors, 118 (81.7-259) pg/mL (p = .16). The serial values also did not show any significant changes; the values at 24 hrs (n = 17), 48 hrs (n = 16), and 96 hrs (n = 15) were 105 (76.1-125.9), 105 (41.4-155.5), and 109.5 (54.9-154.8) pg/mL, respectively. CONCLUSIONS: The results of our study suggest that vasopressin levels are elevated in children with septic shock and that serial values up to 96 hrs do not show any decline.
机译：背景：败血性休克是小儿重症监护病房死亡的重要原因。初步评估表明，加压素可能在成人儿茶酚胺难治性休克中起作用。重要的是要确定败血性休克患儿是否缺乏加压素。这将有助于确定加压素在败血性休克中的作用。设计：前瞻性队列研究。地点：印度北部一家三级护理医院的儿科重症监护室。患者：患者为败血性休克，对照组为败血症但无休克的儿童。研究设计：通过酶联免疫吸附测定法测定诊断为败血性休克的儿童的血浆血浆加压素水平（基线），然后在24、48和96小时确定时间趋势。将败血性休克儿童的基线加压素值与无休克儿童的基线进行比较。结果：败血性休克患儿基线时加压素的中位水平（95％置信区间）为116（63.3-130.7）pg / mL，败血症但无休克患儿为106（61.7-131.77）pg / mL。存活者的中位值为76（44.6-130.9）pg / mL，非存活者的中位值为118（81.7-259）pg / mL（p = .16）。序列值也没有显示任何重大变化; 24小时（n = 17），48小时（n = 16）和96小时（n = 15）的值分别为105（76.1-125.9），105（41.4-155.5）和109.5（54.9-154.8）pg / mL。结论：我们的研究结果表明败血性休克患儿的加压素水平升高，长达96小时的序列值未见任何下降。

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