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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Lack of association between acellular pertussis vaccine and seizures in early childhood.
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Lack of association between acellular pertussis vaccine and seizures in early childhood.

机译：脱细胞百日咳疫苗与儿童癫痫发作之间缺乏关联。

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OBJECTIVES: Receipt of diphtheria-tetanus-whole-cell pertussis vaccine (diphtheria-tetanus toxoids-pertussis [DTP]) is associated with seizures. Limited population-based studies have been conducted on the risk for seizures after receipt of diphtheria-tetanus-acellular pertussis vaccine (diphtheria-tetanus-acellular pertussis [DTaP]). METHODS: We conducted a retrospective study from 1997-2006 by using risk-interval cohort and self-controlled case series (SCCS) analyses on automated data at 7 managed care organizations that participate in the Vaccine Safety Datalink (VSD). Eligible children included the 1997-2006 VSD cohort of patients who were aged 6 weeks to 23 months and had not received DTP during the study period. A seizure event (febrile or afebrile) was defined by International Classification of Diseases, Ninth Revision, Clinical Modification diagnoses assigned to an inpatient or emergency department setting. The exposed period was composed of a predefined 4 person-days after each DTaP dose. All of the remaining observation periods outside the exposed periods were categorized as unexposed. The risk-interval cohort method compared the incidence of seizures between the exposed and unexposed cohorts. In the SCCS method, the comparison was performed between the same patient's exposed and unexposed period. RESULTS: We identified 7191 seizure events among 433,654 children. The adjusted incidence rate ratio of seizures across all doses was 0.87 in cohort analysis and 0.91 in SCCS analysis. CONCLUSIONS: We did not observe an increased risk for seizures after DTaP vaccination among children who were aged 6 weeks to 23 months. These findings provide reassuring evidence on the safety of DTaP with respect to seizures.
机译：目的：白喉-破伤风-全细胞百日咳疫苗的接收（白喉-破伤风类毒素-百日咳[DTP]）与癫痫发作有关。关于接受白喉-破伤风-无细胞百日咳疫苗（白喉-破伤风-百日咳疫苗[DTaP]）后癫痫发作风险的有限人群研究。方法：我们对1997-2006年的7项参与疫苗安全数据链接（VSD）的管理医疗机构的自动化数据进行了风险区间队列和自控病例系列（SCCS）分析，进行了回顾性研究。符合条件的儿童包括1997-2006年的VSD队列，年龄在6周至23个月之间，并且在研究期间未接受DTP。根据分配给住院或急诊科的《国际疾病分类》，《第九次修订版》，《临床改变》诊断定义了癫痫发作（发热或发热）。暴露期由每次DTaP剂量后的预定4个人日组成。暴露期以外的所有其余观察期均归为未暴露期。风险间隔队列方法比较了暴露人群和未暴露人群的癫痫发作发生率。在SCCS方法中，在同一患者的暴露时间和未暴露时间之间进行比较。结果：我们确定了433654名儿童中的7191例癫痫发作。队列分析中所有剂量癫痫发作的调整发病率比率在队列分析中分别为0.87和在SCCS分析中为0.91。结论：我们未观察到DTaP疫苗接种后6周至23个月大的儿童发生癫痫发作的风险增加。这些发现为DTaP在癫痫发作中的安全性提供了令人放心的证据。

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