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首页> 外文期刊>Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology >Breastfeeding and wheeze prevalence in pre-schoolers and pre-adolescents: The Genesis and Healthy Growth studies
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Breastfeeding and wheeze prevalence in pre-schoolers and pre-adolescents: The Genesis and Healthy Growth studies

机译：学龄前儿童和青少年前期的母乳喂养和喘息流行：成因和健康成长研究

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Background: To date, extensive research has been undertaken on a potential link of breastfeeding (BF) to wheezing illnesses. Nevertheless, an association remains to be established, partly due to age-dependent discrepancies and different definitions of exposures/outcomes across studies. We thus investigated the relation of diverse infantile feeding patterns with wheeze/asthma prevalence in two cohorts of children of different ages (preschool and preadolescent). Methods: Wheeze ever/in the last 12 months (current) and doctor-diagnosed asthma were retrospectively reported by parents of the participants of two cross-sectional studies: the Genesis study (1871 children aged 1-5) and the Healthy Growth study (1884 children aged 9-13). Information on feeding practices (exclusive breastfeeding vs. mixed vs. formula feeding) and their duration (2 vs. 4 vs. 6 months) was recorded. Perinatal and anthorpometric data were also collected. Results: In pre-schoolers, regimes that did not entail exclusive BF were positively correlated to current/ever wheeze, both before and after adjustment for confounders. No differences between the associations of regimes with 2, 4 or 6 months of exclusive BF with current/ever wheeze were shown. Furthermore, there was no consistent correlation of feeding practices with physician-diagnosed asthma. In pre-adolescents, no association of infantile feeding patterns with the wheeze/asthma outcomes was observed. Conclusions: Exclusive BF is associated with reduced prevalence of current/ever wheeze in pre-schoolers; however, this appears to wane in older children. The association of a period of exclusive BF as low as 2 months with pre-school wheeze prevalence, appeared to be comparable with that of 6 months of exclusivity.
机译：背景：迄今为止，已经对母乳喂养与喘息性疾病的潜在联系进行了广泛的研究。然而，仍然有待建立联系，部分原因是年龄差异和研究间暴露/结果的不同定义。因此，我们调查了两个不同年龄段的儿童（学龄前和青春期）人群中各种婴儿喂养方式与喘息/哮喘患病率的关系。方法：两项横断面研究的参与者的父母回顾性地报告了过去/最近12个月（现在）的喘息和医生诊断的哮喘：创世纪研究（1871岁的1-5岁儿童）和健康成长研究（ 1884名9-13岁的儿童）。记录有关喂养方式（独家母乳喂养，混合喂养与配方喂养）及其持续时间（2个月，4个月和6个月）的信息。还收集了围产期和人体解剖学数据。结果：在学龄前儿童中，在混杂因素调整之前和之后，没有专属BF的制度与当前/以往的喘息呈正相关。没有显示在有2、4或6个月独家BF与当前/曾经喘息的治疗方案之间的差异。此外，喂养方式与医生诊断的哮喘没有一致的相关性。在青春期前，未观察到婴儿喂养方式与喘息/哮喘结局的关联。结论：独家BF与学龄前儿童当前/曾经患喘息的患病率降低有关。然而，这似乎在大一点的孩子中消失了。低至2个月的独家BF时间与学龄前喘息患病率的相关性似乎与6个月的排他性患病率相当。

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