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首页> 外文期刊>Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology >Comparison of the allergenicity of Actinidia deliciosa (kiwi fruit) and Actinidia chinensis (gold kiwi).
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Comparison of the allergenicity of Actinidia deliciosa (kiwi fruit) and Actinidia chinensis (gold kiwi).

机译：猕猴桃猕猴桃和中华猕猴桃（金猕猴桃）的致敏性比较。

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摘要

Actinidia chinensis (gold kiwi) is a newly available fruit which has been shown to have in vitro immunoglobulin E (IgE) cross-reactivity with green kiwi. This is the first study to investigate clinical reactivity of gold kiwi. Five patients clinically allergic to green kiwi were investigated by skin test and double-blind placebo controlled food challenge (DBPCFC) with gold kiwi fruit. IgE-binding patterns of individual sera from the five challenged patients and a pool of sera from a further nine patients with kiwi allergy were compared in the two fruits by Western blotting. Cross reactivity of proteins in the two fruits was assessed by inhibition of immunoblots and by IgE enzyme-linked immunosorbent assay (ELISA) inhibition. Four of the five patients had a positive DBPCFC to gold kiwi. Western blotting showed marked differences in the allergen patterns of green and gold kiwi. However, inhibition of the immunoblots and ELISA assay reveals extensive inhibition of IgE binding to proteins in each fruit by the alternative species. Gold kiwi fruit is allergenic and patients allergic to green kiwi are at risk of reacting to the gold kiwi fruit. Despite having different protein profiles and IgE-binding patterns, the two species have proteins that extensively cross-inhibit the binding to IgE.
机译：中华猕猴桃（黄金猕猴桃）是一种新近获得的水果，已显示与绿色猕猴桃具有体外免疫球蛋白E（IgE）交叉反应性。这是研究金猕猴桃临床反应性的第一项研究。通过皮肤测试和金猕猴桃双盲安慰剂对照食物激发（DBPCFC）调查了五名临床上对绿色奇异果过敏的患者。通过Western印迹法比较了两个水果中五名挑战患者的个体血清的IgE结合模式和另外九名猕猴桃过敏性患者的血清池。通过抑制免疫印迹和通过IgE酶联免疫吸附测定（ELISA）抑制来评估两种水果中蛋白质的交叉反应性。五名患者中有四名的金奇异果DBPCFC阳性。 Western印迹显示绿色和金色猕猴桃的过敏原模式存在明显差异。但是，对免疫印迹和ELISA分析的抑制显示了替代物种对每种水果中IgE与蛋白质结合的广泛抑制。黄金奇异果具有致敏性，对绿色奇异果过敏的患者可能会对黄金奇异果产生反应。尽管具有不同的蛋白质谱和IgE结合模式，但这两个物种均具有广泛交叉抑制与IgE结合的蛋白质。

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