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首页> 外文期刊>Pediatric dentistry >Gingival enlargement in pediatric organ transplant recipients in relation to tacrolimus-based immunosuppressive regimens.
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Gingival enlargement in pediatric organ transplant recipients in relation to tacrolimus-based immunosuppressive regimens.

机译：与基于他克莫司的免疫抑制方案相关的小儿器官移植受者的牙龈增大。

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PURPOSE: Tacrolimus, in contrast to cyclosporine, has not been found to be associated with gingival enlargement (GE) among adult transplant recipients. The purpose of this study was to explore the prevalence of GE in relation to tacrolimus and cyclosporine-based immunosuppressive regimens among pediatric solid-organ transplant recipients, controlling for the use of calcium channel blockers (CCB) and the presence of supragingival plaque. METHODS: A standardized questionnaire was administered and a comprehensive oral examination was performed among pediatric renal and liver transplant recipients who were at least 6 months post-transplant. RESULTS: The prevalence of GE among 133 participants was 26%, with the highest incidence among subjects receiving cyclosporine and CCB (60%) and the lowest among those receiving tacrolimus without CCB (13%). A multivariate model showed that the odds of having GE were 5 times higher among children receiving cyclosporine than in those not receiving this medication, and 4 times higher among boys than girls. Supragingival plaque and the use of CCB, however, were not found to be associated with GE. CONCLUSION: This study revealed that tacrolimus was not associated with gingival enlargement while cyclosporine remains a risk factor for the development of this condition in pediatric renal and liver transplant recipients.
机译：目的：与环孢菌素相比，他克莫司与成年移植受者的牙龈增大（GE）没有关系。这项研究的目的是探讨小儿实体器官移植受者中与他克莫司和环孢素为基础的免疫抑制方案有关的GE的流行情况，控制钙通道阻滞剂（CCB）的使用和龈上斑的存在。方法：对至少在移植后六个月的小儿肾脏和肝脏移植受者进行了标准化问卷调查，并进行了全面的口腔检查。结果：133名参与者中，GE的患病率为26％，在接受环孢素和CCB的受试者中发生率最高（60％），而在未接受CCB的他克莫司受试者中发生率最低（13％）。多元模型显示，接受环孢素治疗的儿童患GE的几率比未接受这种药物治疗的儿童高5倍，而男孩比女孩高4倍。未发现龈上菌斑和使用CCB与GE相关。结论：这项研究表明，他克莫司与牙龈肿大无关，而环孢素仍然是小儿肾脏和肝脏移植受者发生这种情况的危险因素。

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