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首页> 外文期刊>Pediatric surgery international >Serum soluble vascular cell adhesion molecule-1 (VCAM-1) concentrations in children with reflux nephropathy.
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Serum soluble vascular cell adhesion molecule-1 (VCAM-1) concentrations in children with reflux nephropathy.

机译：返流性肾病患儿的血清可溶性血管细胞粘附分子1（VCAM-1）浓度。

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摘要

Systemic inflammatory disorders causing renal tissue damage do so by the adherence of polymorphonuclear leukocytes to endothelium, a process that is mediated by cell surface adhesion molecules. We determined the circulating levels of serum vascular cell adhesion molecule-1 (VCAM-1) in vesicoureteric reflux (VUR) patients and investigated the relationship between serum VCAM-1, grade of VUR, and secondary renal scarring. Serum levels of VCAM-1 were measured in 53 children aged between 3 months and 15 years with VUR (13 had grade III, 29 had grade IV, and 11 had grade V) and 25 controls using ELISA. Radionuclide scanning was used to assess renal scarring. Renal scarring was found in 29 of the 53 subjects. Serum VCAM-1 was significantly higher in subjects with high grades of VUR without renal scarring (grade IV: 715.9+/-121.0 ng/ml; grade V: 778.5+/-33.2ng/ml) compared with subjects with grade III VUR without renal scarring (609.8+/-64.3ng/ml, p<0.01). Serum VCAM-1 was also significantly higher in subjectswith high grades of VUR with renal scarring (grade IV: 791.2+/-131.9ng/ml; grade V: 1171.8+/-235.6 ng/ml) compared with subjects with grade III VUR with renal scarring (687.3+/-163.4 ng/ml, p<0.001).
机译：引起肾组织损伤的全身性炎症性疾病是通过多形核白细胞与内皮的粘附来实现的，该过程由细胞表面粘附分子介导。我们确定了膀胱输尿管反流（VUR）患者的血清血管细胞粘附分子1（VCAM-1）的循环水平，并研究了血清VCAM-1，VUR等级与继发性肾脏瘢痕形成之间的关系。使用ELISA测定了53例3个月至15岁的VUR患儿的血清VCAM-1水平（13例为III级，29例为IV级，11例为V级）和25例对照。放射性核素扫描用于评估肾脏瘢痕形成。 53名受试者中有29名发现肾脏瘢痕形成。与没有肾瘢痕形成的高级别VUR的受试者（IV级：715.9 +/- 121.0 ng / ml; V级：778.5 +/- 33.2ng / ml）的血清VCAM-1明显高于无III级VUR的受试者肾脏瘢痕形成（609.8 +/- 64.3ng / ml，p <0.01）。肾瘢痕形成高级别VUR的患者（IV级：791.2 +/- 131.9ng / ml; V级：1171.8 +/- 235.6 ng / ml）的血清VCAM-1也显着高于III级VUR和肾疤痕的患者。肾脏瘢痕形成（687.3 +/- 163.4 ng / ml，p <0.001）。

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