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首页> 外文期刊>Pediatric surgery international >Four cases of desmosis coli: severe chronic constipation, massive dilatation of the colon, and hypoperistalsis due to of changes in the colonic connective-tissue net.
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Four cases of desmosis coli: severe chronic constipation, massive dilatation of the colon, and hypoperistalsis due to of changes in the colonic connective-tissue net.

机译：大肠杆菌脱皮的四例：严重的慢性便秘，结肠的大面积扩张和由于结肠结缔组织网的变化而引起的蠕虫病。

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摘要

We present four patients 5, 10, 12, and 17 years of age, each with a long history of severe constipation and hypoperistalsis of the gut. Three had partial or total resection of the colon, all had enterostomies, and only one maintains normal bowel function after reanastomosis. We report the clinical courses, radiologic findings, and operative procedures for all four cases. Preoperative full-thickness biopsies and the resected colon specimens revealed a complete or incomplete lack of the mesh network of collagen. The connective-tissue layer between the circular and longitudinal muscles was missing. Contrary to expectations, the enteric nervous system (ENS) was normal or near-normal in the affected areas. Hypo- and dysganglionosis was found additionally in some proximal segments of colon and/or small bowel. This combination of clinical symptoms and pathological findings is called desmosis of the colon with reference to a working hypothesis in a preliminary report by Meier-Ruge in 1998. Aplastic or hypoplastic desmosis may be the reason for the disturbed gut motility. Histologic examination should thus not only exclude changes of the ENS.
机译：我们介绍了4位5、10、12和17岁的患者，每位患者都有严重的便秘和肠道蠕动病的悠久历史。 3例进行了部分或全部结肠切除术，所有均进行了肠切开术，只有1例在再吻合后保持了正常的肠功能。我们报告所有四个病例的临床过程，影像学发现和手术程序。术前全层活检和切除的结肠标本显示胶原网状网络完全或不完全缺乏。圆形和纵向肌肉之间的结缔组织层缺失。与预期相反，患病区域的肠道神经系统（ENS）正常或接近正常。在结肠和/或小肠的一些近端部分还发现了低神经节和神经节异常。在1998年Meier-Ruge的初步报告中，结合工作假设，将临床症状和病理结果的这种结合称为结肠脱皮。再生障碍或发育不良性脱皮可能是肠蠕动受阻的原因。因此，组织学检查不仅应排除ENS的变化。

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