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首页> 外文期刊>Pediatric dermatology >Purified Type I Collagen Wound Matrix Improves Chronic Wound Healing in Patients with Recessive Dystrophic Epidermolysis Bullosa
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Purified Type I Collagen Wound Matrix Improves Chronic Wound Healing in Patients with Recessive Dystrophic Epidermolysis Bullosa

机译：纯化的I型胶原伤口基质可改善隐性营养不良性表皮松解性大疱患者的慢性伤口愈合

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Recessive dystrophic epidermolysis bullosa is a severe genetic blistering skin condition resulting in chronic wounds. Nonhealing wounds were treated over 8weeks using a reconstituted natural purified type I collagen skin substitute. Chronic wounds were defined as nonhealing wounds present for longer than 6months. For each patient, two chronic wounds were identified and randomized into a control or treatment group. Both groups received standard-of-care wound dressings. The treatment group received an additional type I collagen skin substitute. Wound size was measured at baseline and weeks 1, 4, and 8. Pain, pruritus, and burning and stinging were assessed. Wound cultures were obtained at baseline and thereafter as was considered clinically relevant. Ten subjects were enrolled; seven completed the study. Six subjects showed a positive response to the type I collagen skin substitute. Three subjects demonstrated full wound reepithelialization. Wounds treated using the collagen skin substitute showed statistically significantly greater improvement. Average scores for pruritus and pain decreased significantly. Reconstituted natural purified type I collagen skin substitutes improved the healing of chronic wounds and may be a valuable addition to the epidermolysis bullosa wound care arsenal.
机译：隐性营养不良性表皮松解性大疱是一种严重的遗传性水疱性皮肤病，可导致慢性伤口。使用复原的天然纯化I型胶原蛋白皮肤替代品治疗伤口8周以上无​​法愈合。慢性伤口定义为存在超过6个月的不愈合伤口。对于每位患者，确定了两个慢性伤口并将其随机分为对照组或治疗组。两组均接受护理标准伤口敷料。治疗组接受了另一种I型胶原蛋白皮肤替代品。在基线以及第1、4和8周测量伤口大小。评估疼痛，​​瘙痒以及烧灼和刺痛。在基线获得伤口培养物，然后认为具有临床意义。招募了十名受试者;七个完成了研究。六名受试者对I型胶原蛋白皮肤替代品呈阳性反应。三名受试者表现出全伤口再上皮化。使用胶原蛋白皮肤替代物治疗的伤口在统计学上显示出明显更大的改善。瘙痒和疼痛的平均得分显着下降。重构的天然纯化I型胶原蛋白皮肤替代品改善了慢性伤口的愈合，可能是对大疱性表皮松解伤口护理库的重要补充。

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