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首页> 外文期刊>Pediatric dermatology >Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options
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Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options

机译：儿童糠疹性糠疹：临床表现和治疗选择的回顾

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Pityriasis lichenoides (PL) is a skin condition of unclear etiology that occurs not uncommonly in childhood. It is often classified into the acute form, pityriasis lichenoides et varioliformis acuta (PLEVA), and the chronic form, pityriasis lichenoides chronica (PLC). We performed a comprehensive review of the English-language literature using the PubMed database of all cases of childhood PL reported from 1962 to 2014 and summarized the epidemiology, clinical features, treatment options, and prognosis of this condition in children. The proposed etiologies are discussed, including its association with infectious agents, medications, and immunizations and evidence for PL as a lymphoproliferative disorder. We found an average age of PL onset of 6.5years, with a slight (61%) male predominance. We also found that PLEVA and PLC tend to occur with equal frequency and that, in many cases, there is clinical and histopathologic overlap between the two phenotypes. When systemic therapy is indicated, we propose that oral erythromycin and narrowband ultraviolet B phototherapy should be first-line treatment options for children with PL since they have been shown to be effective and well tolerated. In most cases, PL follows a benign course with no greater risk of cutaneous T-cell lymphoma, although given the rare case reports of transformation, long-term follow-up of these patients is recommended.
机译：地衣糠疹是一种病因不明的皮肤病，在儿童时期并不罕见。它通常分为急性形式的糠疹糠疹和糠疹（PLEVA），以及慢性形式的糠疹糠疹（PLC）。我们使用1962年至2014年期间报告的所有儿童PL病例的PubMed数据库对英语文献进行了全面的回顾，并总结了该病在儿童中的流行病学，临床特征，治疗选择和预后。讨论了所提出的病因，包括其与传染原，药物和免疫的关系，以及PL为淋巴增生性疾病的证据。我们发现PL发病的平均年龄为6.5岁，男性占轻微（61％）。我们还发现PLEVA和PLC倾向于以相等的频率发生，并且在许多情况下，两种表型在临床和组织病理学上有重叠。当指示全身治疗时，我们建议口服红霉素和窄带紫外线B光疗应该是PL儿童的一线治疗选择，因为它们已被证明有效且耐受性良好。在大多数情况下，PL遵循良性病程，没有皮肤T细胞淋巴瘤的更大风险，尽管鉴于罕见的转化病例报告，建议对这些患者进行长期随访。

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