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首页> 外文期刊>Biomaterials >In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery.
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In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery.

机译：在基于多糖的纳米凝胶中原位固定量子点，以整合光学pH传感，肿瘤细胞成像和药物递送。

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We report a class of polysaccharide-based hybrid nanogels that can integrate the functional building blocks for optical pH-sensing, cancer cell imaging, and controlled drug release into a single nanoparticle system, which can offer broad opportunities for combined diagnosis and therapy. The hybrid nanogels were prepared by in-situ immobilization of CdSe quantum dots (QDs) in the interior of the pH and temperature dual responsive hydroxypropylcellulose-poly(acrylic acid) (HPC-PAA) semi-interpenetrating polymer networks. The-OH groups of the HPC chains are designed to sequester the precursor Cd(2+) ions into the nanogels as well as stabilize the in-situ formed CdSe QDs. The pH-sensitive PAA network chains are designed to induce a pH-responsive volume phase transition of the hybrid nanogels. The developed HPC-PAA-CdSe hybrid nanogels combine a strong trap emission at 741nm for sensing physicochemical environment in a pH dependent manner and a visible excitonic emission at 592nm for mouse melanoma B16F10 cell imaging. The hybrid nanogels also provide excellent stability as a drug carrier, which cannot only provide a high drug loading capacity for a model anticancer drug temozolomide, but also offer a pH-triggered sustained-release of the drug molecules in the gel network.
机译：我们报告了一类基于多糖的杂合纳米凝胶，可以将光学pH传感，癌细胞成像和药物控制释放的功能构建模块整合到单个纳米颗粒系统中，这可以为组合诊断和治疗提供广阔的机会。通过将CdSe量子点（QDs）原位固定在pH和温度双响应羟丙基纤维素-聚（丙烯酸）（HPC-PAA）半互穿聚合物网络内部来制备杂化纳米凝胶。 HPC链的-OH基团旨在将前体Cd（2+）离子螯合到纳米凝胶中，并稳定原位形成的CdSe QD。 pH敏感的PAA网络链设计为诱导杂化纳米凝胶的pH响应体积相转变。已开发的HPC-PAA-CdSe杂合纳米凝胶结合了741nm处的强陷阱发射，以pH依赖性方式感测理化环境，以及592nm处的可见激子发射，用于小鼠黑素瘤B16F10细胞成像。杂化纳米凝胶还具有出色的稳定性，可作为药物载体，不仅可以为模型抗癌药物替莫唑胺提供高载药量，还可以在凝胶网络中提供pH触发的药物分子缓释。

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