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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Resistance of epiphyseal cartilage to invasion by osteosarcoma is likely to be due to expression of antiangiogenic factors.
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Resistance of epiphyseal cartilage to invasion by osteosarcoma is likely to be due to expression of antiangiogenic factors.

机译：骨phy对骨肉瘤侵袭的抵抗力很可能归因于抗血管生成因子的表达。

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OBJECTIVES: Epiphyseal cartilage is a barrier to osteosarcoma invasion, however the mechanisms behind this resistance remain unclear. The aim of this study was to examine the chronological and spatial patterns of osteosarcoma growth and invasion of local tissue structures including epiphyseal cartilage. METHODS: We used an in vivomouse model of osteosarcoma to histologically examine tumors at different stages of disease progression. We compared the pattern of osteosarcoma penetration of epiphyseal cartilage with the expression pattern of two potent mediators of angiogenesis; proangiogenic vascular endothelial growth factor (VEGF) and antiangiogenic pigment epithelium-derived factor (PEDF). RESULTS: Epiphyseal cartilage remained intact across its entire length in all sections examined, despite increasing tumor size as well as intra- and extraosseous destruction. In the most advanced cases, only the proangiogenic lowermost layers of the hypertrophic zone of the growth plate were eroded. This correspondedwith the growth plate layers which highly expressed the angiogenic factor VEGF. In contrast, the resting, proliferative and upper hypertrophic layers were resistant to osteosarcoma invasion in all cases. This corresponded to the layers with the highest expression of the potent antiangiogenic factor PEDF. CONCLUSION: Epiphyseal cartilage is resistant to local invasion by osteosarcoma. The balance of angiogenesis, influenced by pro- and antiangiogenic factors, is likely to play an important role in this resistance.
机译：目的：Epi骨软骨是骨肉瘤浸润的障碍，但是这种抵抗的机制尚不清楚。这项研究的目的是检查骨肉瘤生长和侵袭包括tissue软骨在内的局部组织结构的时间和空间格局。方法：我们使用了骨肉瘤的体内小鼠模型来组织学检查疾病进展不同阶段的肿瘤。我们比较了骨肉瘤penetration骨软骨的渗透模式和血管生成的两种有效介质的表达模式。促血管新生血管内皮生长因子（VEGF）和抗血管生成色素上皮衍生因子（PEDF）。结果：尽管肿瘤大小增加以及骨内和骨外破坏，但在所有检查的切片中，骨s软骨在整个长度上均保持完整。在最先进的情况下，仅侵蚀生长板肥大区的促血管生成最低层。这对应于高表达血管生成因子VEGF的生长板层。相反，在所有情况下，休息层，增生层和肥厚上层均对骨肉瘤的侵袭具有抵抗力。这对应于有效抗血管生成因子PEDF的最高表达层。结论：Epi骨软骨对骨肉瘤的局部侵袭具有抵抗力。血管生成的平衡受促血管生成因子和抗血管生成因子的影响，很可能在这种抗药性中起重要作用。

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