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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Immunohistochemical analysis of inflammatory cells in benign and precancerous lesions and carcinoma of the prostate
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Immunohistochemical analysis of inflammatory cells in benign and precancerous lesions and carcinoma of the prostate

机译：良性和癌前病变和前列腺癌中炎性细胞的免疫组织化学分析

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Objective: Inflammation is an important cause of tumorigenesis in various types of malignancy. Mediators derived from inflammatory cells are associated with cancer proliferation, angiogenesis, and DNA damage. In the present study, we immunohistochemically examined the infiltration patterns of inflammatory cells in benign glands including glandular hyperplasia, and in prostatic intraepithelial neoplasia and adenocarcinoma. Methods: Formalin-fixed, paraffin-embedded tissues were obtained from 100 patients with prostate cancer. All patients underwent radical prostatectomy. We assessed the number of infiltrating T cells (CD3+), B cells (CD20+, CD79alpha+), and macrophages (CD68+, CD204+) in benign and malignant prostate tumors. Results: CD68+ macrophages infiltrated benign glands to a higher extent than those of adenocarcinoma. In contrast, the number of CD204+ cells was higher in malignant glands than in benign glands. There was no significant difference in the number of infiltrating T cells between benign and malignant tumors; however, the number of infiltrating B cells was significantly reduced in malignant glands. Conclusions: Inflammation of the prostate may act on prostate carcinomas; particularly that involving M2 macrophage infiltration may play a significant role in prostate carcinogenesis.
机译：目的：炎症是各种类型恶性肿瘤中肿瘤发生的重要原因。源自炎症细胞的介体与癌症增殖，血管生成和DNA损伤有关。在本研究中，我们免疫组织化学检查了包括腺体增生在内的良性腺以及前列腺上皮内瘤变和腺癌中炎性细胞的浸润模式。方法：从100例前列腺癌患者中获得福尔马林固定，石蜡包埋的组织。所有患者均接受了前列腺癌根治术。我们评估了良性和恶性前列腺肿瘤中浸润性T细胞（CD3 +），B细胞（CD20 +，CD79alpha +）和巨噬细胞（CD68 +，CD204 +）的数量。结果：CD68 +巨噬细胞浸润良性腺的程度高于腺癌。相比之下，恶性腺中CD204 +细胞的数量要多于良性腺。良性和恶性肿瘤之间浸润性T细胞数量没有显着差异。然而，在恶性腺中浸润的B细胞数量明显减少。结论：前列腺炎症可能作用于前列腺癌。特别是涉及M2巨噬细胞浸润的物质可能在前列腺癌的发生中起重要作用。

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