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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >TP53 status and response to chemotherapy in breast cancer.
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TP53 status and response to chemotherapy in breast cancer.

机译：TP53的状态和对乳腺癌的化学反应。

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Despite its central role in the control of apoptosis, senescence and cell cycle arrest, the tumor suppressor protein p53 remains an enigma for its possible role in predicting response to chemotherapy in cancer patients. Many studies remained inconclusive, others showed a better response for tumors with normal p53, and some recent studies showed adverse effects of normal p53 for response to treatment. p53 is not only a powerful pro-apoptotic factor in response to drug-induced DNA damages but also a potential inducer of cell cycle arrest, protecting tumor cells from further cytotoxic damages. Our review describes the classical as well as the more recent concepts. In order to draw definite conclusions, future works should use more reliable methods to assess the TP53 status and should address more homogeneous tumor subpopulations treated with homogeneous chemotherapy regimens.
机译：尽管其在控制细胞凋亡，衰老和细胞周期停滞中起着中心作用，但抑癌蛋白p53仍是谜，因为它在预测癌症患者对化学疗法的反应中可能发挥作用。许多研究尚无定论，另一些研究显示对p53正常的肿瘤有更好的反应，而一些近期研究显示正常p53对治疗的不良反应。 p53不仅是对药物诱导的DNA损伤有反应的强大促凋亡因子，而且还是细胞周期停滞的潜在诱导剂，可保护肿瘤细胞免受进一步的细胞毒性损伤。我们的评论描述了经典以及最近的概念。为了得出明确的结论，未来的工作应使用更可靠的方法来评估TP53的状态，并应对采用同种化学疗法治疗的同种肿瘤亚群。

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