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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >EphB1 is underexpressed in poorly differentiated colorectal cancers.
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EphB1 is underexpressed in poorly differentiated colorectal cancers.

机译：EphB1在低分化大肠癌中表达不足。

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BACKGROUND: Over- or underexpression of certain Eph receptors has been associated with tumorigenesis of some types of cancer. EphB1 is a member of receptor tyrosine kinases of the EphB subfamily involved in the development, progress and prognosis of colorectal cancers. The expression levels of EphB1 in colon cancer cell lines and human colorectal carcinoma specimens were determined and association of EphB1 expression with clinicopathological parameters was analyzed. METHODS: Quantitative real-time reverse transcription polymerase chain reaction and immunohistochemistry were used. RESULTS: The EphB1 transcript is expressed in all colon cancer cell lines tested. However, there is marked variability in the expression of the EphB1 transcripts and proteins among colorectal carcinoma specimens. Reduced expression of EphB1 in colorectal cancers more often occurred in poorly differentiated and mucinous adenocarcinomas than in well- and moderately differentiated adenocarcinomas. Further, cancer cells with a lowlevel of EphB1 protein showed more invasive power. CONCLUSION: Our data indicate that EphB1 may have roles in the pathogenesis and development of colorectal cancer.
机译：背景：某些Eph受体的过度表达或表达不足与某些类型的癌症的肿瘤发生有关。 EphB1是EphB亚家族的受体酪氨酸激酶的成员，参与大肠癌的发生，发展和预后。测定EphB1在结肠癌细胞系和人结肠直肠癌标本中的表达水平，并分析EphB1表达与临床病理参数的关系。方法：采用实时定量逆转录聚合酶链反应和免疫组化方法。结果：EphB1转录本在所有测试的结肠癌细胞系中都有表达。但是，大肠癌标本中EphB1转录本和蛋白质的表达存在明显差异。与低分化和高分化腺癌相比，低分化和粘液性腺癌中EphB1的表达减少更为常见。此外，EphB1蛋白水平低的癌细胞显示出更大的侵袭力。结论：我们的数据表明EphB1可能在大肠癌的发病和发展中起作用。

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