• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Translational Research in Breast Cancer
【24h】

Translational Research in Breast Cancer

机译：乳腺癌转化研究

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent advances in our knowledge of the molecular and cellular biology of cancer have emerged from the laboratory. The resulting challenge has been how to turn these advances in knowledge into advances in the clinic as rapidly and practically as possible.For breast cancer, the challenge is even more important as the incidence and total burden of disease is increasing rapidly worldwide. Even if the number of breast cancer survivors is increasing, the harm and distress associated with the diagnosis and treatment of breast cancer challenge both bench-orientated research and public health work. Knowing very well that breast cancer is not one single disease, the scientific community strives to obtain biological information of different types of breast cancer linked to clinical data such as overall survival, disease-free survival or quality of life. In addition, among the well-categorized histological subtypes and the groupings delivered by receptor status, research tries to further investigate the existenceof associations between well-established and newly recognized biological and phenotypicfeatures involved in tumor prognosis [1]. Another way of tackling the complexity of breast cancer was to utilize gene expression profiling technology [2]. Gene expression measurements from breast cancer have almost become clinical predictive tools to identify tumor subtypes, patients showing poor/good prognosis and patients likely to have disease recurrence. This evolution in the laboratory and clinical research has stimulated an interest in potential results that could be directly used in the dailyroutine. This also explains the interest of a larger public in these issues; breast cancer activists are willing to take up a role in the creation of biological and clinical databases. Patients are asked to lobby for and help in clinical studies. On the other hand, the access to human tissues is only possible via the patient. The discussion around the Human Tissue Act in Britain may serve as one example [3].
机译：实验室已显示出我们对癌症分子和细胞生物学的最新认识。随之而来的挑战是如何将这些知识的进步尽快，切实地转化为临床的进步。对于乳腺癌，随着全世界范围内疾病的发病率和总负担迅速增加，这一挑战变得更加重要。即使乳腺癌幸存者的数量在增加，与乳腺癌的诊断和治疗相关的伤害和困扰也对面向实验室的研究和公共卫生工作提出了挑战。科学界非常了解乳腺癌不是一种疾病，因此，科学界努力获取与临床数据相关的不同类型乳腺癌的生物学信息，例如整体生存率，无病生存率或生活质量。此外，在分类良好的组织学亚型和受体状态分组之间，研究试图进一步研究在肿瘤预后中已建立的和新近公认的生物学和表型特征之间的关联[1]。解决乳腺癌的复杂性的另一种方法是利用基因表达谱分析技术[2]。乳腺癌的基因表达测量几乎已成为识别肿瘤亚型，预后不良/良好的患者以及可能复发的患者的临床预测工具。实验室和临床研究的这种发展激发了人们对可能直接用于日常工作的潜在结果的兴趣。这也解释了广大公众对这些问题的兴趣;乳腺癌活动家愿意在生物学和临床数据库的创建中发挥作用。要求患者游说以帮助临床研究。另一方面，只能经由患者进入人体组织。关于英国《人类组织法》的讨论可以作为一个例子[3]。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号