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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Immunohistochemical analysis of cell cycle-related molecules in gastric carcinoma: prognostic significance, correlation with clinicopathological parameters, proliferation and apoptosis.
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Immunohistochemical analysis of cell cycle-related molecules in gastric carcinoma: prognostic significance, correlation with clinicopathological parameters, proliferation and apoptosis.

机译：胃癌中细胞周期相关分子的免疫组织化学分析：预后意义，与临床病理参数，增殖和凋亡的相关性。

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摘要

OBJECTIVE: We aimed to investigate the biological significance of cell cycle regulators in gastric carcinoma. METHODS: Immunohistochemistry and TUNEL staining were performed on tissue array slides containing 293 gastric carcinoma specimens. The relationship between the protein expression of each of the cell cycle regulators and prognosis, clinicopathological features, proliferation, or apoptosis was evaluated. RESULTS: The nuclear immunoreactivity for cyclin D1, cyclin E, p21, and p27 was observed in 22, 14, 31 and 27% of cases, respectively. The expression of cyclin D1, p21, or p27 positively correlated with early pTNM stages, tumor cell proliferation (represented by Ki-67 labeling) and good prognosis, whereas it inversely correlated with the lymph node metastasis (p < 0.05). On the other hand, p27 expression inversely correlated with the apoptosis index represented by TUNEL staining (p < 0.001). In addition, the expression of cyclin D1 positively correlated with that of p21 or p27 (p < 0.05). CONCLUSIONS: Our results showed that the expression of cyclin D1, p21 and p27, alone or in combination, are early events in gastric tumorigenesis and may serve as a candidate molecular marker for the early gastric carcinoma.
机译：目的：探讨胃癌细胞周期调控因子的生物学意义。方法：对包含293例胃癌标本的组织阵列载玻片进行免疫组织化学和TUNEL染色。评估每种细胞周期调节剂的蛋白质表达与预后，临床病理特征，增殖或凋亡之间的关系。结果：分别在22％，14％，31％和27％的病例中观察到细胞周期蛋白D1，细胞周期蛋白E，p21和p27的核免疫反应性。 cyclin D1，p21或p27的表达与pTNM早期阶段，肿瘤细胞增殖（以Ki-67标记）和预后良好呈正相关，而与淋巴结转移呈负相关（p <0.05）。另一方面，p27表达与TUNEL染色所代表的凋亡指数呈负相关（p <0.001）。另外，细胞周期蛋白D1的表达与p21或p27正相关（p ＜0.05）。结论：我们的结果表明，细胞周期蛋白D1，p21和p27的单独或组合表达是胃癌发生的早期事件，并可作为早期胃癌的候选分子标记。

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