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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Imbalance of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases: a novel approach for explaining the parenchymal liquefaction of the septic spleen?
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Imbalance of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases: a novel approach for explaining the parenchymal liquefaction of the septic spleen?

机译：基质金属蛋白酶-1和金属蛋白酶组织抑制剂的失衡：解释败血症性脾实质液化的一种新方法？

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OBJECTIVE: The causal pathophysiological mechanisms involved in the parenchymal liquefaction of the septic spleen are still far from clear. The balance between matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), is largely responsible for the remodelling of tissues. Deregulation of this balance is a characteristic of extensive tissue degradation in certain chronic inflammatory diseases. METHODS: This study focuses on a search for alterations in the balance between MMP-1 (interstitial collagenase) and TIMP-1 by means of immunostaining, by immunoblotting, and by gel zymography. RESULTS: We found a deregulation of the balance between MMP-1 and TIMP-1 in the septic spleen in favor of the active form of MMP-1. CONCLUSION: Our findings suggest that active MMP-1 is involved in collagenolytic extracellular matrix breakdown in the septic spleen.
机译：目的：化脓性脾实质液化的病因病理生理机制尚不清楚。基质金属蛋白酶（MMP）及其抑制剂（金属蛋白酶的组织抑制剂）之间的平衡在很大程度上负责组织的重塑。这种平衡的失调是某些慢性炎性疾病中广泛组织降解的特征。方法：本研究的重点是通过免疫染色，免疫印迹和凝胶酶谱法研究MMP-1（间质胶原酶）和TIMP-1之间的平衡变化。结果：我们发现化脓性脾脏中MMP-1和TIMP-1之间的平衡失调，有利于MMP-1的活性形式。结论：我们的研究结果表明，活跃的MMP-1参与化脓性脾脏胶原蛋白分解细胞外基质的分解。

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