首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >A unique case of an indolent myometrial T-Cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells
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A unique case of an indolent myometrial T-Cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells

机译:表现为类似于子宫CD8 +常驻记忆T细胞的表型特征的惰性子宫肌层T细胞淋巴增生性疾病的独特案例

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Objective: Indolent extranodal T-cell lymphoproliferative disorders have recently been described as new entities in the gastrointestinal tract and acral sites displaying clonal T-cell receptor (TCR) rearrangement and nonactivated cytotoxic CD8+ T-cell phenotypes.Methods/Results: We report a unique case of an atypical myometrial T-cell lymphoproliferation in a 39-year-old multiparous woman, which shares many of the features mentioned above: CD8+/TIA1+/granzyme B- phenotype, clonal TCR rearrangement and indolent course.Conclusion(s): We hypothesize that it might derive from a subset of uterine nonrecirculating CD8+ resident memory T cells expanded after repeated exposure to alloextravillous trophoblastic antigen.
机译:目的:惰性淋巴结外T细胞淋巴增生性疾病最近被描述为在胃肠道和and骨部位的新实体,表现出克隆性T细胞受体(TCR)重排和未激活的细胞毒性CD8 + T细胞表型。方法/结果:我们报道了一种独特的一个39岁的多胎妇女的非典型肌层T细胞淋巴增生的病例,其具有上述许多特征:CD8 + / TIA1 + /粒酶B-表型,TCR克隆重排和病程缓慢。结论:假设它可能源自子宫非循环性CD8 +常驻记忆T细胞的子集,该子集是在反复暴露于同种异态绒毛滋养细胞抗原后扩增的。

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