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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Expression of reactive oxygen species-related proteins according to androgen and HER-2 status in estrogen receptor-negative breast cancer
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Expression of reactive oxygen species-related proteins according to androgen and HER-2 status in estrogen receptor-negative breast cancer

机译：雌激素受体阴性乳腺癌中根据雄激素和HER-2状态的活性氧相关蛋白的表达

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Objective: The purpose of the current study is to understand the clinicopathological implications of redox proteins in association with androgen receptor (AR) and HER-2 status in estrogen receptor (ER)-negative breast cancers through evaluation of the expression patterns of redox proteins, such as catalase, thioredoxin reductase (TxNR), glutathione Stransferase p (GSTp), thioredoxin interacting protein (TxNIP), and manganese superoxide dismutase (MnSOD).Methods: Two hundred cases of ER-negative breast cancer samples were collected as a tissue microarray. Immunohistochemical staining was done for redox-related proteins, after which the resulting data set was organized by AR and HER-2 status.Results: The redox proteins that had a significant association with AR and HER-2 status were tumoral catalase (p < 0.001) and stromal GSTp (p < 0.001). Tumoral catalase was least expressed in the AR-/HER-2- group, while stromal GSTp was least expressed in both the AR+/HER-2- and the AR-/HER-2- groups. Stromal GSTp was highly expressed in HER-2 positive groups (p < 0.001). Stromal GSTp negativity and tumoral MnSOD positivity were associated with a shorter diseasefree survival (p = 0.041 and p = 0.007, respectively) in univariate analysis.Conclusion: ER-negative breast cancers showed different expressions of redox-related proteins ac-cording to AR and HER-2 status. Catalase expression was high in AR-negative groups, while stromal GSTp expression was high in HER-2-positive groups.
机译：目的：本研究的目的是通过评估氧化还原蛋白的表达模式，了解氧化还原蛋白与雄激素受体（AR）和HER-2状态在雌激素受体（ER）阴性乳腺癌中的临床病理关系，方法：收集200例ER阴性乳腺癌样本作为组织微阵列，如过氧化氢酶，硫氧还蛋白还原酶（TxNR），谷胱甘肽转移酶p（GSTp），硫氧还蛋白相互作用蛋白（TxNIP）和锰超氧化物歧化酶（MnSOD）。 。对氧化还原相关蛋白进行了免疫组织化学染色，然后根据AR和HER-2状态组织了数据集。结果：与AR和HER-2状态显着相关的氧化还原蛋白是肿瘤过氧化氢酶（p <0.001） ）和基质GSTp（p <0.001）。肿瘤过氧化氢酶在AR- / HER-2-组中表达最少，而间质GSTp在AR + / HER-2-和AR- / HER-2-组中表达最少。基质GSTp在HER-2阳性组中高表达（p <0.001）。在单因素分析中，间质GSTp阴性和肿瘤MnSOD阳性与较短的无病生存期相关（分别为p = 0.041和p = 0.007）。结论：ER阴性乳腺癌的AR和AR表现出不同的氧化还原相关蛋白表达HER-2状态。 AR阴性组的过氧化氢酶表达较高，而HER-2阳性组的间质GSTp表达较高。

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