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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Histological Features and Tissue Microarray Taxonomy of Nigerian Breast Cancer Reveal Predominance of the High-Grade Triple-Negative Phenotype
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Histological Features and Tissue Microarray Taxonomy of Nigerian Breast Cancer Reveal Predominance of the High-Grade Triple-Negative Phenotype

机译：尼日利亚乳腺癌的组织学特征和组织芯片分类学揭示了高级三阴性表型的优势。

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Introduction: Little is known about the biology, molecular profile and hence optimal treatment of African Nigerian breast cancer. The aim of this work, therefore, was to characterize the histology and molecular profile of Nigerian breast cancer. Methods: Breast carcinomas from women at 6 centres of similar tribal origin in Nigeria were reviewed and assembled into tissue microarrays (TMAs), and sections were stained for hormone receptors, i. e. estrogen receptor (ER) a, ER beta 1, ER alpha progesterone receptor (PR) and androgen receptor, cyclin D, HER2, Ki67 and cytokeratins (CKs), i. e. CK5/6 and CK14 (basal) and CK18 and 19 (luminal). Results: A total of 835 tumours were analysed. The mean age at diagnosis was 48.62 +/- 12.41 years. The most common histological subtype was ductal NST (no-special-type) carcinoma (87.3%). Over 90% of the tumours were grade 2 or 3. The predominant molecular phenotype was the non-basal, triple-negative type (47.65%) followed by the HER2-positive group (19.6%). The percentage of ER-, PR-and HER2-positive tumours was 22.4, 18.9 and 18.8%, respectively. Conclusion: Nigerian breast cancer predominantly has a high-grade, triple-negative profile. It occurs at a younger age and bears similarities at the molecular level to pre-menopausal breast cancer in white women, with remarkably lower levels of ER beta expression. The early presentation and histological and molecular phenotype may explain the poor prognosis, and tailoring treatment strategies to target this unique profile are required. (C) 2016 S. Karger AG, Basel
机译：简介：关于非洲尼日利亚乳癌的生物学，分子特征以及因此的最佳治疗知之甚少。因此，这项工作的目的是表征尼日利亚乳腺癌的组织学和分子特征。方法：回顾了来自尼日利亚类似部落起源的6个中心的妇女的乳腺癌，并将其组装到组织微阵列（TMA）中，并对切片进行激素受体染色，即e。雌激素受体（ER）a，ERβ1，ERα孕激素受体（PR）和雄激素受体，细胞周期蛋白D，HER2，Ki67和细胞角蛋白（CKs），i。 e。 CK5 / 6和CK14（基础）和CK18和19（内腔）。结果：共分析了835个肿瘤。诊断时的平均年龄为48.62 +/- 12.41岁。最常见的组织学亚型是导管NST（非特殊类型）癌（87.3％）。超过90％的肿瘤为2级或3级。主要的分子表型为非基础的三阴性类型（47.65％），其次是HER2阳性组（19.6％）。 ER，PR和HER2阳性肿瘤的百分比分别为22.4、18.9和18.8％。结论：尼日利亚乳腺癌主要具有高度的三阴性特征。它发生在更年轻的年龄，并且在分子水平上与白人妇女绝经前乳腺癌具有相似性，并且ERβ表达水平明显降低。早期表现以及组织学和分子表型可能解释了不良的预后，因此需要针对这种独特的情况制定治疗策略。 （C）2016 S.Karger AG，巴塞尔

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