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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Distribution of PD-1+ lymphocytes in reactive lymphadenopathies.
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Distribution of PD-1+ lymphocytes in reactive lymphadenopathies.

机译：PD-1 +淋巴细胞在反应性淋巴腺病中的分布。

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OBJECTIVES: Programmed death-1 (PD-1) is physiologically expressed by germinal center (GC)-associated helper T cells. It has been proposed that an increase in PD-1+ cells outside GC could indicate pattern I angioimmunoblastic T-cell lymphoma (AITL). METHODS: We studied the distribution of PD-1+ cells in reactive lymphadenopathies (LA), including HIV-associated and dermatopathic LA (n = 5, each), Castleman (n = 3), Kikuchi (n = 2) and Rosai-Dorfman diseases (n = 1), sarcoidoses (n = 7) and follicular hyperplasias (n = 8). RESULTS: The highest concentrations of PD-1+ cells in GC were found in Castleman and Rosai-Dorfman diseases (mean 57 and 50% of total cells, respectively), and the lowest in HIV-associated LA (mean 6%). The highest proportions in paracortices were found in Castleman disease, and in HIV-associated and dermatopathic LA (mean 7, 3 and 2%, respectively). PD-1+ cells predominated in the pale zones of GC in follicular hyperplasia. In HIV-associated LA, PD-1+ cells showed marked marginalization in the GC. No paracortical PD-1+ cells were found in sarcoidoses and Rosai-Dorfman disease. CONCLUSIONS: The varying distribution of PD-1+ cells in defined LA might indicate a functional relevance of these cells in the respective entities. Since increased numbers of PD-1+ cells outside GC are observed in various LA, this finding might not be entirely specific for pattern I AITL.
机译：目的：程序性死亡1（PD-1）由生发中心（GC）相关的辅助T细胞在生理上表达。有人提出，GC外PD-1 +细胞的增加可能表明I型血管免疫母细胞性T细胞淋巴瘤（AITL）。方法：我们研究了PD-1 +细胞在反应性淋巴腺病（LA）中的分布，包括HIV相关性和皮肤病性LA（n = 5，每个），Castleman（n = 3），Kikuchi（n = 2）和Rosai-多夫曼病（n = 1），肌瘤病（n = 7）和滤泡增生（n = 8）。结果：GC中PD-1 +细胞的最高浓度在Castleman和Rosai-Dorfman疾病中（分别占总细胞的57和50％），在HIV相关的LA中最低（平均6％）。在Castleman病以及与HIV相关和皮肤病的LA中，皮层旁皮比例最高（分别为7％，3％和2％）。 PD-1 +细胞在滤泡性增生的GC苍白区占主导。在与HIV相关的LA中，PD-1 +细胞在GC中显示出明显的边缘化。在肌节病和Rosai-Dorfman病中未发现皮质旁PD-1 +细胞。结论：定义的LA中PD-1 +细胞的分布变化可能表明这些细胞在各自实体中的功能相关性。由于在各种LA中观察到GC外的PD-1 +细胞数量增加，因此该发现可能并不完全适用于模式I AITL。

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