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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease
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Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease

机译：血清肿瘤坏死因子升高与增生性视网膜病变的视网膜缺血增加有关

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Objective: Tumor necrosis factor (TNF) was evaluated in the serum of patients with proliferative stage of Eales' disease to study its relation with the area of retinal capillary non-perfusion (ischemic retina). Methods: Quantification of the levels of TNF was done using sandwich ELISA in 52 cases with proliferative Eales' disease and in 32 healthy controls. Seven 50° photographs of different fields of the fundus were taken on fluorescein angiography. The area of retinal capillary non-perfusion denoting retinal cell death was assessed in terms of optic disc areas. Results: TNF levels were found to be significantly increased in the proliferative stage of the disease (mean 23.64 ± 3.7 pg/ml) as compared to controls (mean 12.49 ± 2.9 pg/ml; p < 0.001). Higher levels of TNF were found to be associated with an increased area of retinal capillary non-perfusion on fluorescein angiography. TNF levels of 20-31 pg/ml were observed in cases with neovascularization at the disc (n = 33) as compared to 17-21 pg/ml in cases with neovascularization elsewhere (n = 19). Conclusions: An increasedlevel of TNF is associated with an increased area of the ischemic retina. It is hypothesized that retinal cell death signaling in proliferative Eales' disease is related to an increased TNF level.
机译：目的：评估Eales病增生期患者血清中的肿瘤坏死因子（TNF），以探讨其与视网膜毛细血管非灌注（缺血性视网膜）面积的关系。方法：采用夹心酶联免疫吸附测定法对52例增生性Eales病患者和32例健康对照者的TNF水平进行了定量。在荧光素血管造影上拍摄了七张不同眼底区域的50°照片。根据视盘面积评估表示视网膜细胞死亡的视网膜毛细血管非灌注区域。结果：与对照组（平均12.49±2.9 pg / ml）相比，在疾病的增生阶段TNF水平显着增加（平均23.64±3.7 pg / ml）（p <0.001）。在荧光素血管造影上发现较高的TNF水平与视网膜毛细血管非灌注面积增加有关。椎间盘处新血管形成的患者（n = 33）的TNF水平为20-31 pg / ml，而其他部位新血管形成的患者（n = 19）的TNF水平为17-21 pg / ml。结论：TNF水平升高与缺血性视网膜面积增加有关。假设增生性Eales病中的视网膜细胞死亡信号转导与TNF水平升高有关。

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