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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Correlation of autophagy type in podocytes with histopathological diagnosis of IgA nephropathy.
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Correlation of autophagy type in podocytes with histopathological diagnosis of IgA nephropathy.

机译：足细胞自噬类型与IgA肾病的组织病理学诊断的相关性。

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OBJECTIVE: IgA nephropathy (IgA-N) frequently leads to progressive renal failure, thus estimation of the degree of progression is important for patient management. Autophagy is a mechanism that facilitates clearance of waste products to preserve renal function. The aim of this study was to assess autophagy in podocytes in children with progressive IgA-N at initial diagnosis by electron microscopy and investigate the relationship between the types of autophagy and severity of the disease. METHODS: Renal biopsies from 16 children with established progressive IgA-N were examined by light and transmission electron microscopy with reference to autophagy types in the podocytes and histopathological diagnosis of IgA-N. RESULTS: Two autophagy types were found. Type I rarely transformed to autophagic vacuoles and did not dissolve, thus possibly impairing cell function. However, type II frequently transformed to autophagosomes and autophagic vacuoles thus facilitating protein and lipid clearance. Of the 16 children studied, 8 (50%) with type I autophagy at initial diagnosis showed focal proliferative glomerulosclerosis (GN) of mild type (3 cases, 37.5%), mild/moderate type (2 cases, 25%) and moderate type (3 cases, 37.5%). In contrast, the remaining 8 children with type II autophagy at initial diagnosis showed focal proliferative GN of mild type in 7 (87.5%) and mild/moderate type in 1 (12.5%) case. CONCLUSION: In IgA-N children, the occurrence of type I autophagy is correlated with histopathologically more progressive disease, possibly reflecting a tendency to a poorer prognosis.
机译：目的：IgA肾病（IgA-N）经常导致进行性肾衰竭，因此评估进展程度对于患者管理很重要。自噬是一种有助于清除废物以保持肾功能的机制。这项研究的目的是通过电子显微镜在初诊时评估进展性IgA-N儿童的足细胞自噬，并研究自噬类型与疾病严重程度之间的关系。方法：参照足细胞自噬类型和IgA-N的组织病理学诊断，通过光镜和透射电镜检查16例进展性IgA-N患儿的肾脏活检。结果：发现了两种自噬类型。 I型很少转化为自噬泡并且不溶解，因此可能损害细胞功能。然而，II型经常转化为自噬体和自噬泡，从而促进蛋白质和脂质的清除。在研究的16名儿童中，初诊断为I型自噬的8名儿童（50％）显示轻度型（3例，37.5％），轻度/中度型（2例，25％）和中度型的局灶性增生性肾小球硬化（GN） （3例，37.5％）。相反，其余8例初诊为II型自噬的儿童在7例（87.5％）的轻度型和1例（12.5％）的轻度/中度型的局灶性增殖性GN中表现出。结论：在IgA-N儿童中，I型自噬的发生与组织病理学上更进展的疾病有关，可能反映了预后较差的趋势。

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