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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >p16ink4a is a surrogate marker for high-risk and malignant cervical lesions in the presence of human papillomavirus.
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p16ink4a is a surrogate marker for high-risk and malignant cervical lesions in the presence of human papillomavirus.

机译：p16ink4a是存在人类乳头瘤病毒的高危和恶性宫颈病变的替代标志物。

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OBJECTIVE: To strengthen the role of high-risk human papillomaviruses (HPVs) in the development of cervical cancer, and the association between HPV and the cell cycle inhibitor gene p16ink4a in cervical carcinogenesis. METHODS: In this study, the association between p16ink4a and the presence of HPV DNA in cervical lesions was investigated in a total of 177 cervical biopsies classified as benign (n = 42), low-grade squamous intraepithelial lesions (LSIL; n = 34), high-grade squamous intraepithelial lesions (HSIL; n = 48) and invasive cancer (n = 53). p16ink4a expression was analyzed by immunohistochemistry while HPV DNA was localized by in situ hybridization. RESULTS: No significant association was found between p16ink4a expression and HPV presence in benign and LSIL samples. In HSIL and invasive cancer, a significant association was found between p16ink4a overexpression and the presence of HPV DNA. CONCLUSION: Immunohistochemical p16ink4a expression is associated with HPV infection in HSIL and cervical cancer, suggesting a role of p16 as a biomarker of HPV-associated cervical lesions.
机译：目的：增强高危型人乳头瘤病毒（HPVs）在宫颈癌发展中的作用，以及HPV与细胞周期抑制剂基因p16ink4a在宫颈癌发生中的关系。方法：在这项研究中，对总共177例被分类为良性（n = 42），低度鳞状上皮内病变（LSIL; n = 34）的宫颈活检组织，研究了p16ink4a与宫颈病变中HPV DNA的存在之间的关系。 ，高度鳞状上皮内病变（HSIL; n = 48）和浸润性癌症（n = 53）。通过免疫组织化学分析p16ink4a表达，同时通过原位杂交定位HPV DNA。结果：在良性和LSIL样品中，p16ink4a表达与HPV的存在之间没有显着关联。在HSIL和浸润性癌症中，发现p16ink4a过表达与HPV DNA的存在显着相关。结论：免疫组化p16ink4a表达与HSIL和宫颈癌中的HPV感染有关，提示p16作为HPV相关宫颈病变的生物标志物的作用。

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