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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Inflammatory infiltrates and neovessels are relevant sources of MMPs in abdominal aortic aneurysm wall.
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Inflammatory infiltrates and neovessels are relevant sources of MMPs in abdominal aortic aneurysm wall.

机译：炎症性浸润和新血管是腹主动脉瘤壁中MMP的相关来源。

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OBJECTIVES: Abdominal aortic aneurysm (AAA) wall is characterized by degradation of extracellular matrix through matrix metalloproteinases (MMPs), chronic inflammatory cell infiltration and extensive neovascularization. So far, MMP expression within AAA wall in association with infiltrates and neovascularization has not yet been studied. METHODS: Vessel walls of 15 AAA patients and 8 organ donors were analyzed by immunohistochemistry for expression of various MMPs (MMP-1, -2, -3, -7, -8, -9, -12 and -13) in all cells located within the AAAs and correlated with infiltrates and neovascularization. RESULTS: Luminal endothelial cells (ECs) were positive for MMP-1, -3 and -9, ECs of mature neovessels were furthermore positive for MMP-2. Immature neovessels expressed all MMPs tested except for MMP-13. Aortic medial smooth muscle cells (SMCs) expressed MMP-1, -2, -3 and -9, SMCs of mature neovessels, only MMP-1, -3 and -9. Inflammatory infiltrates expressed all MMPs tested except for MMP-2, macrophages expressed all MMPs. Infiltrates were composed mainly of B cells (58.5 +/- 10.9%) and T lymphocytes (26.3 +/- 9.5%). Furthermore, significant inverse correlations were found between the amounts of inflammatory cells, neovessels and collagen/elastin content of the aortic vessel wall (r = +0.806/p < 0.001, r = -0.650/p = 0.012, r = -0.63/p < 0.015; respectively). CONCLUSION: Inflammatory infiltrates and invading neovessels are relevant sources of MMPs in the AAA wall and may substantially contribute to aneurysm wall instability.
机译：目的：腹主动脉瘤（AAA）壁的特征是通过基质金属蛋白酶（MMP），慢性炎症细胞浸润和广泛的新血管形成使细胞外基质降解。迄今为止，尚未研究AAA壁内的MMP表达与浸润和新血管形成有关。方法：采用免疫组织化学方法分析15例AAA患者和8例器官供体的血管壁在所有细胞中各种MMPs（MMP-1，-2，-3，-7，-8，-9，-12和-13）的表达。位于AAA中，并与浸润和新血管形成相关。结果：腔内皮细胞（ECs）MMP-1，-3和-9呈阳性，成熟新生血管的ECsMMP-2呈阳性。未成熟的新生血管表达了除MMP-13以外的所有MMP。主动脉内侧平滑肌细胞（SMC）表达MMP-1，-2，-3和-9，成熟新生血管的SMC仅表达MMP-1，-3和-9。炎性浸润表达了除MMP-2以外的所有MMP，巨噬细胞表达了所有MMP。浸润主要由B细胞（58.5 +/- 10.9％）和T淋巴细胞（26.3 +/- 9.5％）组成。此外，在主动脉血管壁的炎症细胞数量，新血管和胶原蛋白/弹性蛋白含量之间发现显着的负相关关系（r = + 0.806 / p <0.001，r = -0.650 / p = 0.012，r = -0.63 / p <0.015;分别）。结论：炎性浸润和侵犯新血管是AAA壁中MMP的相关来源，可能在很大程度上导致动脉瘤壁不稳定。

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