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Phytochemicals as modulators of neoplastic phenotypes.

机译:植物化学物质作为肿瘤表型的调节剂。

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摘要

It is generally accepted that nutritional behaviors constitute decisive components of human health. Phytochemicals (small, nonenergetic molecules of vegetal origin) are overall inhibitory on the expression of gene products promoting proliferation and resistance to apoptosis. On the contrary, phytochemicals stimulate the synthesis of adaptive proteins that favor resistance to cellular stress (detoxifying and antioxidant enzymes). They are effective modulators that act synergistically on membrane, cytoplasmic and nuclear enzymatic reactions to dampen cellular hyperproliferation and hyperactivity, reequilibrate metabolic activity and promote apoptosis of genetically unstable cells. Despite important gaps in our knowledge regarding how phytochemicals interfere with cellular function in vivo, effective chemopreventive measures have shown that phytochemicals can be utilized to prevent cancer, and possibly to treat cancer patients as well. We review how phytochemicals exert their beneficial effects at the cellular level.
机译:人们普遍认为营养行为是人类健康的决定性组成部分。植物化学物质(植物性的小的非能量分子)总体上抑制促进增殖和抗凋亡的基因产物的表达。相反,植物化学物质刺激适应性蛋白质的合成,这些蛋白质有利于抵抗细胞应激(解毒和抗氧化酶)。它们是有效的调节剂,可协同作用于膜,细胞质和核酶反应,以抑制细胞过度增殖和过度活跃,重新平衡代谢活性并促进遗传不稳定细胞的凋亡。尽管我们在植物化学物质如何干扰体内细胞功能方面的知识方面存在重大差距,但有效的化学预防措施表明植物化学物质可用于预防癌症,也可能用于治疗癌症患者。我们回顾了植物化学物质如何在细胞水平上发挥其有益作用。

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