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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Symmetric division and expression of its regulatory gene Numb in human cervical squamous carcinoma cells.
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Symmetric division and expression of its regulatory gene Numb in human cervical squamous carcinoma cells.

机译：在人类宫颈鳞状细胞癌细胞中的调控基因Numb的对称分裂和表达。

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OBJECTIVE: To investigate the mode of cell division and Numb expression in cervical squamous cells. METHOD: We measured the cleavage angles of cervical squamous epithelia basal cells and Numb protein expression in 50 cases of cervical squamous cell carcinomas (CSCC), 59 cervical intraepithelial neoplasias (CIN) grade II-III, 21 CIN grade I and 48 controls. RESULTS: We found an increase in horizontal divisions in CIN grade I and a decrease in horizontal divisions in CIN grade II-III. Numb expression had a tendency to be stronger from control to CSCC. In CSCC there was a significantly higher expression of mRNA for the Numb-PRRL isoform but not for the Numb-PRRS isoform. CONCLUSION: Our findings suggest that in the initial stage of CSCC, carcinomatous cells may acquire an increase of symmetric division by altering cleavage orientation and proliferation. Expression of Numb protein in Cervical squamous epithelia and an increased expression of Numb-PRRL isoforms may be among the mechanisms involved in the genesis of CSCC.
机译：目的：探讨宫颈鳞状细胞的细胞分裂方式和Numb表达方式。方法：我们测量了50例宫颈鳞状细胞癌（CSCC），59例宫颈上皮内瘤变（CIN）II-III级，21例CIN I级和48例对照的宫颈鳞状上皮基底细胞的裂解角度和Numb蛋白表达。结果：我们发现CIN I级的水平分隔增加了，而CIN II-III级的水平分隔减少了。从控制到CSCC，麻木表达趋于增强。在CSCC中，Numb-PRRL亚型的mRNA表达显着升高，而Numb-PRRS亚型的mRNA则没有。结论：我们的研究结果表明，在CSCC的初始阶段，癌细胞可能会通过改变裂解方向和增殖而增加对称分裂。 Numb蛋白在宫颈鳞状上皮细胞中的表达和Numb-PRRL亚型的表达增加可能是CSCC发生的机制之一。

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