• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Expression of p53 protein in esophageal squamous cell carcinoma: relation to hypoxia-inducible factor-1alpha, angiogenesis and apoptosis.
【24h】

Expression of p53 protein in esophageal squamous cell carcinoma: relation to hypoxia-inducible factor-1alpha, angiogenesis and apoptosis.

机译：p53蛋白在食管鳞状细胞癌中的表达：与低氧诱导因子1α，血管生成和细胞凋亡的关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: Hypoxia-inducible factor (HIF)-1 is important in the control of transcription of several genes related to angiogenesis. We have previously reported that expression of HIF-1alpha correlates with venous invasion and clinical outcome in esophageal squamous cell carcinoma. p53 has been reported to interact with HIF-1alpha and induce ubiquitin-mediated proteosomal degradation of HIF-1alpha. The purpose of this study was to clarify whether the expression of p53 is associated with that of HIF-1alpha. METHODS: Expression of p53, HIF-1alpha and vascular endothelial growth factor (VEGF) was examined in 81 archival surgical specimens of human esophageal squamous cell carcinoma tissue. CD34 and single-stranded DNA were used to evaluate angiogenesis and apoptosis. RESULTS: Forty-seven of the 81 (58.0%) tumor specimens showed high levels of nuclear p53 immunoreactivity. Overexpression of p53 was observed in the early clinical stage of tumor development. Expression of p53 was not correlated with HIF-1alpha or VEGF expression, angiogenesis or apoptosis in esophageal carcinoma. CONCLUSIONS: These results suggest that mutations in p53 play a role in carcinogenesis but not in the progression of esophageal squamous cell carcinoma. HIF-1alpha may not only be regulated by p53 but also by other factors.
机译：目的：缺氧诱导因子（HIF）-1在控制与血管生成有关的几个基因的转录中很重要。我们以前曾报道过，HIF-1alpha的表达与食管鳞状细胞癌中的静脉浸润和临床结果相关。据报道，p53与HIF-1alpha相互作用并诱导泛素介导的HIF-1alpha蛋白质组降解。这项研究的目的是澄清p53的表达是否与HIF-1alpha相关。方法：在81例人食管鳞状细胞癌组织手术标本中检测p53，HIF-1α和血管内皮生长因子（VEGF）的表达。 CD34和单链DNA用于评估血管生成和凋亡。结果：81个肿瘤标本中有47个（58.0％）显示出高水平的核p53免疫反应性。在肿瘤发展的临床早期阶段观察到p53的过度表达。在食管癌中，p53的表达与HIF-1α或VEGF的表达，血管生成或凋亡无关。结论：这些结果表明p53基因突变在食管癌的发生中起作用，而在食管鳞状细胞癌的进展中不起作用。 HIF-1alpha不仅可能受到p53的调控，还可能受到其他因素的调控。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号