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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Bcl-2 phosphorylation has pathological significance in human breast cancer.
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Bcl-2 phosphorylation has pathological significance in human breast cancer.

机译：Bcl-2磷酸化在人类乳腺癌中具有病理学意义。

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摘要

The anti-apoptotic molecule, Bcl-2, is well known to play an important role in the chemoresistance of breast cancer. We have previously demonstrated that phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine through c-jun NH2-terminal kinase (JNK) activation sensitizes breast cancer cells to chemotherapy through accelerating cell cycle arrest at G2/M, and that Bcl-2 phosphorylation downstream of JNK/FADD plays an important role in cell growth suppression by paclitaxel. In this study, the clinicopathological association of phosphorylated Bcl-2 (P-Bcl-2) with estrogen, progesterone, c-erbB-2 receptors, p53 expressions and phosphorylated FADD/JNK (P-FADD/JNK) was analyzed immunohistochemically using 107 human breast cancer specimens. Expression of P-Bcl-2 was found to significantly correlate with lymphatic invasion, lymph node metastasis, but not histological differentiation, tumor grade or vascular and fatty invasion. The positivity of P-Bcl-2 was also significantly correlated to that of P-FADD/JNK. Thus, P-Bcl-2 as well as the P-FADD/JNK parameter might be useful markers for cancer progression, independent of the hormone receptor status, in human breast cancers.
机译：众所周知，抗凋亡分子Bcl-2在乳腺癌的化学抗性中起重要作用。我们先前已经证明，通过c-jun NH2末端激酶（JNK）激活，在194个丝氨酸上的Fas相关死亡域含蛋白（FADD）的磷酸化可通过加速细胞周期停滞在G2 / M使乳腺癌细胞对化疗敏感，并且JNK / FADD下游的Bcl-2磷酸化在紫杉醇抑制细胞生长中起重要作用。在这项研究中，使用107免疫组织化学分析了磷酸化Bcl-2（P-Bcl-2）与雌激素，孕酮，c-erbB-2受体，p53表达和磷酸化FADD / JNK（P-FADD / JNK）的临床病理联系。人类乳腺癌标本。发现P-Bcl-2的表达与淋巴管浸润，淋巴结转移显着相关，但与组织学分化，肿瘤等级或血管和脂肪浸润无关。 P-Bcl-2的阳性也与P-FADD / JNK的阳性显着相关。因此，在人乳腺癌中，P-Bcl-2以及P-FADD / JNK参数可能是癌症进展的有用标志物，而与激素受体状态无关。

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