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首页> 外文期刊>Biomaterials >A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance.
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A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance.

机译：基于pH响应的介孔二氧化硅纳米颗粒的多药递送系统，可克服多药耐药性。

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摘要

A type of pH-responsive nano multi-drug delivery systems (nano-MDDSs) with uniform particle size (100 +/- 13 nm) and excellent monodispersity was developed by in situ co-self-assembly among water-insoluble anti-cancer drug (doxorubicin, DOX), surfactant micelles (CTAB) as chemosensitiver and silicon species forming drugs/surfactant micelles-co-loaded mesoporous silica nanoparticles (drugs@micelles@MSNs or DOX@CTAB@MSNs) via a micelles-MSNs self-assembly mechanism. The nano-MDDS DOX@CTAB@MSNs had a highly precise pH-responsive drug release behavior both in vitro and in vivo, and exhibited high drug efficiencies against drug-resistant MCF-7/ADR cells as well as drug-sensitive MCF-7 cells by the MSNs-mediated transmembrane delivery, the sustained drug release and the high anti-cancer and multi-drug resistance (MDR)-overcoming efficiencies. The MDR-overcoming mechanism was proved to be a synergistic cell cycle arrest/apoptosis-inducing effect resulted from the chemosensitization of the surfactant CTAB. These results demonstrated a very promising nano-MDDS for the pH-responsive controlled drug release and the cancer MDR overcoming.
机译：通过在水不溶性抗癌药物中原位共组装，开发了一种具有pH响应性的纳米多药递送系统（nano-MDDSs），该系统具有均一的粒径（100 +/- 13 nm）和出色的单分散性（阿霉素，DOX），表面活性剂胶束（CTAB）作为化学敏感剂和硅物质形成药物/表面活性剂胶束-共同负载的介孔二氧化硅纳米粒子（drugs @ micelles @ MSNs或DOX @ CTAB @ MSNs）通过胶束-MSNs自组装机制。纳米MDDS DOX @ CTAB @ MSNs在体外和体内均具有高度精确的pH响应药物释放行为，并且对耐药MCF-7 / ADR细胞和对药物敏感的MCF-7表现出较高的药效细胞通过MSNs介导的跨膜递送，持续的药物释放以及高的抗癌和多药耐药性（MDR）克服效率。证明MDR克服机制是表面活性剂CTAB的化学增敏作用产生的协同细胞周期阻滞/凋亡诱导作用。这些结果证明了用于pH响应控制药物释放和克服癌症MDR的非常有前景的纳米MDDS。

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