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首页> 外文期刊>Pferdeheilkunde >Assessment of cannon bone mineral density by dual X-ray absorptiometry (DXA) in horses? [German]Original Title Ist die mobile Dual-Rontgen-Absorptiometrie (DEXA) zur Knochendichtemessung der Rohrbeine beim Pferd geeignet?
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Assessment of cannon bone mineral density by dual X-ray absorptiometry (DXA) in horses? [German]Original Title Ist die mobile Dual-Rontgen-Absorptiometrie (DEXA) zur Knochendichtemessung der Rohrbeine beim Pferd geeignet?

机译：通过双X射线吸收法（DXA）对马中的大炮骨矿物质密度进行评估？ [德语]原标题移动双X线骨密度仪（DEXA）是否适合测量马中拐杖腿的骨密度？

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摘要

DXA (dual energy X-ray absorptiometry) is an established method for the measurement of bone mineral density (BMD), calculated bone mineral content (BMC) and whole body composition in human and partly in veterinary medicine. However, there are only a small number of studies that examine optical bone density in horses using DXA. All these studies are based on small sample sizes. Therefore, the objective of this study was to validate the use of DXA for the measurement of BMD and the calculated BMC in the horse. In total the cannons of 103 horses were scanned ex vivo, using the PIXI LUNARReg. densitometer. The measuring point was the standardized midpoint between basis and caput of the third metacarpal/metatarsal bone. In a second step the DXA measurements were complemented by chemical analysis, using the respective bone slices. In these bone slices bone ash as well as calcium (Ca), phosphorus (P) and magnesium (Mg) content were determined. The average ash content of the cannon bones was 698+or-33.2 g/kg dry matter (DM). The average mineral content was measured in the following order: Ca 268+or-21.1 g/kg DM, P 124+or-8.36 g/kg DM und Mg 2.42+or-0.305 g/kg DM. The ratio of Ca to P ranged from 2.14 to 2.18. The DXA results are influenced not only by the bone's mineral content, but also by its diameter. Based on this, the results are separated into the results of the forelimb (fl) and the hindlimb (hl) which generated the following results: BMD: fl 3.20 g/cm2, hl 4.11 g/cm2; BMC: fl 25.95 g/cm3, hl 32.75 g/cm3. Several robustness checks of the measurements were conducted. For the BMD measurements, the range varied by 3.51-4.48% for measurements with limb repositioning, and by 1.06-1.85% for measurements without limb repositioning. For the calculated BMC measurements, the range varied from 3.38-3.94% for measurements with limb repositioning, and by 1.28-2.79 for measurements without limb repositioning. To determine the importance of the exact bone position for follow-up investigations, measurements in a distance of one, two and three centimeters proximal and distal of the original measuring point were performed. The results of these measurements deviated from the result of the central measuring point at the centre of the diaphysis in a range of 5.19 to 11.8%. Overall, the results of this study indicate that DXA is suitable for determining BMD and calculated BMC at the third metacarpal/metatarsal bone of the horse. The high reproducibility of the results and the distance measurements suggest that DXA is suitable for measurements at the standing, tranquilized horse. However, the cannon bone is a tissue with a high content of cortical bone. This means that the diameter of the bone changes as a result of training or immobilization, while the bone ash content remains unchanged by such influence. This leads to a weak correlation between the results from the DXA and chemical analyses like bone ash or Ca, P and Mg. Thus, while these two types of analysis fit well into the context of prior studies, a direct comparison between these measurements is not possible.
机译：DXA（双能X线骨密度仪）是一种已建立的方法，用于测量人和部分兽用动物的骨矿物质密度（BMD），计算的骨矿物质含量（BMC）和全身成分。但是，只有少数研究使用DXA检查马的光学骨密度。所有这些研究都是基于小样本量。因此，本研究的目的是验证DXA在测量马的BMD和计算出的BMC中的应用。使用PIXI LUNARReg，总共对103匹马的大炮进行了离体扫描。密度计。测量点是第三掌骨/掌骨的基础和掌骨之间的标准化中点。在第二步中，使用相应的骨切片，通过化学分析对DXA测量结果进行补充。在这些骨切片中，确定骨灰以及钙（Ca），磷（P）和镁（Mg）的含量。大炮骨的平均灰分含量为698+或-33.2 g / kg干物质（DM）。平均矿物质含量按以下顺序测量：Ca 268+或-21.1 g / kg DM，P 124+或-8.36 g / kg DM和Mg 2.42+或-0.305 g / kg DM。 Ca与P之比为2.14至2.18。 DXA结果不仅受骨骼中矿物质含量的影响，还受其直径的影响。基于此，将结果分为前肢（fl）和后肢（hl）的结果，它们产生以下结果：BMD：fl 3.20 g / cm 2 ，hl 4.11 g / cm 2 ; BMC：fl 25.95 g / cm 3 ，hl 32.75 g / cm 3 。进行了几次测量的鲁棒性检查。对于BMD测量，对于肢体重新定位的测量范围，变化范围为3.51-4.48％;对于没有肢体重新定位的测量范围，变化范围为1.06-1.85％。对于计算出的BMC测量值，范围在进行肢体重新定位的情况下变化范围为3.38-3.94％，对于未进行肢体重新定位的测量范围为1.28-2.79。为了确定准确的骨位置对于后续检查的重要性，在原始测量点的近端和远端分别进行了1、2和3厘米的距离测量。这些测量的结果与骨干中央的中心测量点的结果相差5.19至11.8％。总体而言，这项研究的结果表明DXA适用于确定马的第三掌骨/掌骨的BMD和计算的BMC。结果和距离测量的高度可重复性表明DXA适合在站立，安静的马上进行测量。但是，大炮骨是皮质骨含量高的组织。这意味着骨骼的直径由于训练或固定而改变，而骨灰分含量由于这种影响而保持不变。这导致DXA的结果与化学分析（如骨灰或Ca，P和Mg）之间的相关性较弱。因此，尽管这两种类型的分析非常适合先前的研究，但无法直接比较这些测量结果。

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