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首页> 外文期刊>Pharmaceutical Chemistry Journal >BUTOCONAZOLE NITRATE PHARMACOKINETICS STUDIED BY CAPILLARY ELECTROPHORESIS
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BUTOCONAZOLE NITRATE PHARMACOKINETICS STUDIED BY CAPILLARY ELECTROPHORESIS

机译：毛细血管电泳研究硝酸布托康唑硝酸盐药代动力学

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摘要

In view of the wide use of butoconazole nitrate in practical gynecology, a method for determining this drug in the blood of experimental animals has been developed based on capillary electrophoresis. Samples were prepared using sedimentation of plasma proteins by acetonitrile. The separation was carried out at 27癈 in a quartz capillary (75mum diameter, 65 cm working length) at 20 kV. The leading electrolyte was a phosphate buffer solution at pH 3.6. Detection was performed by spectrophotometry at 210 nm. The proposed technique was used to study the pharmacokinetics of butoconazole nitrate in rats upon a single intraperitoneal injection at a dose of 80 mg/kg. The kinetic curves of butoconazole nitrate concentration in the blood were constructed and were typical of drug removal with bile.
机译：鉴于硝酸丁康康唑在实际妇科中的广泛应用，已经开发了一种基于毛细管电泳的测定实验动物血液中这种药物的方法。使用血浆蛋白通过乙腈沉淀来制备样品。分离是在石英毛细管（直径75 mm，工作长度65 cm）中以27 kV在20 kV下进行的。主要电解质是pH 3.6的磷酸盐缓冲溶液。通过分光光度法在210nm处进行检测。拟议的技术用于研究大鼠腹腔内单次注射80 mg / kg硝酸硝酸丁康康唑的药代动力学。建立了血液中硝酸丁康康唑浓度的动力学曲线，这是胆汁中药物清除的典型曲线。

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