GC/MS ANALYSIS OF AQUEOUS ETHANOL SOLUTIONS OF DRUGS. PART 1. MENTHOL AND P-AMINOBENZOIC ACID DERIVATIVES

A. I. Ermakov; Yu. Yu. Khomyakov; L. P. Soshenko; 1; V. G. Plyushchikov1

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GC/MS ANALYSIS OF AQUEOUS ETHANOL SOLUTIONS OF DRUGS. PART 1. MENTHOL AND P-AMINOBENZOIC ACID DERIVATIVES

机译：药物乙醇溶液的GC / MS分析第1部分。薄荷醇和对氨基苯甲酸衍生物

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A joint GC/MS analysis of aqueous and aqueous-ethanol solutions of some drugs including menthol, validol, benzocaine, novocaine, and menovazin has been performed using a Varian 3900/2100T (USA) instrument equipped with a Varian Factor Four VF-5ms capillary column. The structures of some impurities that were previously based on theoretical considerations are confirmed. Structural-analytical possibilities of the latest modification of the Varian GC/MS system with an ion-trap source are investigated. It is possible to obtain clear mass spectra even for low-intensity and partly overlapping chromatographic peaks using the given device combination. The results can be used for quality control of drugs based on the investigated compounds.

机译：使用配备了Varian因子4 VF-5ms毛细管的Varian 3900 / 2100T（USA）仪器，对包括薄荷醇，有效酚，苯佐卡因，novocaine和Menovazin在内的某些药物的水溶液和乙醇水溶液进行了联合GC / MS分析柱。确认了先前基于理论考虑的一些杂质的结构。研究了使用离子阱源对Varian GC / MS系统进行最新修改的结构分析可能性。使用给定的设备组合，即使对于低强度和部分重叠的色谱峰，也可以获得清晰的质谱图。结果可用于基于所研究化合物的药物质量控制。

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来源
《Pharmaceutical Chemistry Journal》 |2009年第8期|共2页
作者
A. I. Ermakov; Yu. Yu. Khomyakov; L. P. Soshenko; 1; V. G. Plyushchikov1;
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正文语种 eng
中图分类药学;
关键词
drugs; menthol; validol; benzocaine; novocaine; menovazin; GC/MS analysis; impurity chemical structure.;

机译：药物;薄荷醇;有效酚;苯佐卡因;新诺卡因;甲萘并嗪;GC / MS分析;杂质化学结构。;

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GC/MS ANALYSIS OF AQUEOUS ETHANOL SOLUTIONS OF DRUGS. PART 1. MENTHOL AND P-AMINOBENZOIC ACID DERIVATIVES

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