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首页> 外文期刊>Pharmaceutical Chemistry Journal >Use of Hydrophilic Interaction Liquid Chromatography to Separate Butylhydroxyanisole Isomers
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Use of Hydrophilic Interaction Liquid Chromatography to Separate Butylhydroxyanisole Isomers

机译：亲水相互作用液相色谱法分离丁基羟基茴香醚异构体

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摘要

The possibility of using columns with nitrile, diol, and amino sorbents to separate butylhydroxyanisole isomers by hydrophilic interaction liquid chromatography was studied. Columns containing nitrile and diol sorbents did not separate butylhydroxyanisole isomers using either hydrophilic interaction liquid chromatography or reverse phase chromatography. Separation of butylhydroxyanisole isomers by reverse phase chromatography was only obtained on a Diasphere 110 C10CN 250 x 4.6 mm, 5 mu m column using acetonitrile:water (50:50) or methanol:water (65:35) as the mobile phase. These isomers could only be separated by hydrophilic interaction chromatography on columns containing an amino sorbent when the acetonitrile level in the mobile phase was greater than 97%. Columns containing amino sorbents had greater selectivity for butylhydroxyanisole isomers than columns containing C18 sorbents in reverse phase chromatography. Better isomer separation was obtained on Zorbax NH(2)150 x 4.6 mm, 5 mu m columns with a mobile phase acetonitrile content of 99 - 99.5%.
机译：研究了使用具有腈，二醇和氨基吸附剂的色谱柱通过亲水相互作用液相色谱分离丁基羟基茴香醚异构体的可能性。使用亲水相互作用液相色谱法或反相色谱法，含有腈和二醇吸附剂的色谱柱未分离出丁基羟基茴香醚异构体。仅在乙腈：水（50:50）或甲醇：水（65:35）作为流动相的Diasphere 110 C10CN 250 x 4.6 mm，5μm色谱柱上通过反相色谱分离丁基羟基茴香醚异构体。当流动相中的乙腈含量大于97％时，只能通过在含有氨基吸附剂的色谱柱上通过亲水相互作用色谱法分离这些异构体。含氨基吸附剂的色谱柱对丁基羟基茴香醚异构体的选择性比反相色谱中含C18吸附剂的色谱柱更高。在Zorbax NH（2）150 x 4.6 mm，5μm色谱柱上，流动相乙腈含量为99-99.5％，可获得更好的异构体分离。

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