Pharmacokinetic Studies of the Innovative Antituberculosis Drug Thiozonide in Plasma

Savchenko A. Yu.; Menshikova L. A.; Ramenskaya G. V.; Smolyarchuk E. A.

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Pharmacokinetic Studies of the Innovative Antituberculosis Drug Thiozonide in Plasma

机译：新型抗结核药物硫唑尼德在血浆中的药代动力学研究

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We present here our results from studies of the pharmacokinetic parameters of the original antituberculosis agent thiozonide, 100-mg capsules (ZAO Farm-Sintez, Moscow) using single increasing doses in different groups of healthy volunteers in a phase I clinical trial.

机译：在这里，我们在I期临床试验中，通过对不同组的健康志愿者使用单次递增剂量的原始抗结核药thiozonide 100毫克胶囊（ZAO Farm-Sintez，莫斯科）的药代动力学参数进行研究，得出结果。

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《Pharmaceutical Chemistry Journal》 |2015年第3期|共4页
作者
Savchenko A. Yu.; Menshikova L. A.; Ramenskaya G. V.; Smolyarchuk E. A.;
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正文语种 eng
中图分类药学;
关键词
thiozonide; pharmacokinetics; clinical trials; phase I; plasma;

机译：噻唑酮;药代动力学;临床试验;I期;血浆;

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专利

1. Pharmacokinetic Studies of the Innovative Antituberculosis Drug Thiozonide in Plasma [J] . Savchenko A. Yu., Menshikova L. A., Ramenskaya G. V., Pharmaceutical Chemistry Journal . 2015,第3期

机译：新型抗结核药物硫唑尼德在血浆中的药代动力学研究
2. Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA-824 with concomitant lopinavir-ritonavir, efavirenz, or rifampin [J] . DooleyK.E., LuetkemeyerA.F., ParkJ.-G., Antimicrobial agents and chemotherapy. . 2014,第9期

机译：抗结核药物PA-824与洛匹那韦-利托那韦，依非韦伦或利福平同时使用的第一阶段安全性，药代动力学和药物遗传学研究
3. Meta-analysis of clinical studies supports the pharmacokinetic variability hypothesis for acquired drug resistance and failure of antituberculosis therapy [J] . PasipanodyaJ.G., SrivastavaS., GumboT. Clinical infectious diseases . 2012,第2期

机译：对临床研究的荟萃分析支持了获得性耐药和抗结核治疗失败的药代动力学变异假说
4. Self-Regulating Physiologically Based Pharmacokinetic Model and Creation of Drug Concentration Profiles in Plasma and Tissues [C] . Stanislav Polinkevych International Conference on Bioinformatics Computational Biology . 2011

机译：基于生理的药代动力学模型和血浆和组织中药物浓度谱的创造
5. Investigations of the biodistribution and phototherapeutic utility of two palladium(II)-containing macrocyclic drugs in a tumour-bearing mouse model: A study of the pharmacokinetics and tissue distribution of the potential photodynamic drug palladium-bacteriopheophorbide as well as the in vivo treatment efficacy and tissue distribution of the potential photothermal drug palladium(II) octabutoxynaphthalocyanine. [D] . DeGroot, Jennifer Leanne. 2002

机译：两种含钯（II）的大环药物在荷瘤小鼠模型中的生物分布和光疗实用性的研究：潜在的光动力药物钯-细菌脱镁叶绿酸的药代动力学和组织分布以及体内治疗效果和研究光热药物钯（II）八丁氧基萘酞菁的组织分布。
6. Phase I Safety Pharmacokinetics and Pharmacogenetics Study of the Antituberculosis Drug PA-824 with Concomitant Lopinavir-Ritonavir Efavirenz or Rifampin [O] . Kelly E. Dooley, Anne F. Luetkemeyer, Jeong-Gun Park, 2014

机译：抗结核药物PA-824与洛匹那韦-利托那韦依非韦伦或利福平共同治疗的I期安全性药代动力学和药物遗传学研究
7. Phase I Safety, Pharmacokinetics, and Pharmacogenetics Study of the Antituberculosis Drug PA-824 with Concomitant Lopinavir-Ritonavir, Efavirenz, or Rifampin [O] . Kelly E. Dooley, Anne F. Luetkemeyer, Jeong-Gun Park, 2014

机译：I期安全性，药代动力学和药物研究，抗结核药物PA-824与伴随的Lopinavir-ritonavir，Efavirenz或利福平

Pharmacokinetic Studies of the Innovative Antituberculosis Drug Thiozonide in Plasma

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