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首页> 外文期刊>Pharmaceutical development and technology >Roller compaction: Application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics
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Roller compaction: Application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics

机译：辊压实：带内气带孔隙度计算在优化下游颗粒流动和压实特性方面的应用

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摘要

This paper reports the use of an in-gap ribbon porosity calculation for the optimisation of roller compaction ribbon parameters in order to control downstream granule and tablet properties for a typical pharmaceutical formulation. The study demonstrates the effect of changes to roll speed and roll gap on the relative level of ribbon compaction for ribbons with equivalent in-gap porosities. It is demonstrated that in-gap ribbon porosity can be applied to enable optimization of the downstream granule processability characteristics for a typical pharmaceutical formulation and an understanding of the control space of a roller compaction process.
机译：本文报告了间隙内带状孔隙度的计算方法，用于优化压辊带状参数，以控制典型药物制剂的下游颗粒和片剂特性。该研究表明，对于间隙内孔隙率相等的带材，轧制速度和辊隙的变化对带材压实相对水平的影响。结果表明，间隙带的孔隙率可用于优化典型药物制剂的下游颗粒加工性能，并了解辊压工艺的控制空间。

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