SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME CARBAMATE-CONTAINING AZAHETEROCYCLES

A. V. Velikorodov; V. B. Kovalev; O. V. Degtyarev; O. L. Titova

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SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME CARBAMATE-CONTAINING AZAHETEROCYCLES

机译：某些含氨基甲酸酯氮杂杂环化合物的合成及抗真菌活性

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A series of carbamate-containing derivatives of 1,2- and 1,4-oxazine, isoxazoline, isoxazole, benzifnidazole-3-oxide, and indole were obtained by [3 + 2]-cycloaddition and ring-closure reactions. The antifungal activity of the synthesized compounds was studied in vitro against Microsporum canis, Trichophyton rubrum, and Candida albicans. Among the tested compounds, the maximum antifungal activity was observed for tautomeric 5(6)-alkoxycarboxamido derivatives of 2-ary 1-1 -hydroxybenzimidazole-3-oxide sodium salts and 1,2-oxazines.

机译：通过[3 + 2]-环加成和闭环反应获得了一系列含有1,2-和1,4-恶嗪的氨基甲酸酯的衍生物，异恶唑啉，异恶唑，苯并nidazole-3-氧化物和吲哚。在体外研究了合成化合物对犬小孢子菌，毛癣菌和白色念珠菌的抗真菌活性。在测试的化合物中，观察到2-ary 1-1-羟基苯并咪唑-3-氧化物钠盐和1,2-恶嗪的互变异构5（6）-烷氧基羧酰胺基衍生物的最大抗真菌活性。

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来源
《Pharmaceutical Chemistry Journal》 |2011年第10期|共4页
作者
A. V. Velikorodov; V. B. Kovalev; O. V. Degtyarev; O. L. Titova;
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正文语种 eng
中图分类药学;
关键词
carbamate-containing azaheterocycles; cycloaddition and ring-closure reactions; antifungal activity.;

机译：含氨基甲酸酯的氮杂杂环;环加成和闭环反应;抗真菌活性。;

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1. SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME CARBAMATE-CONTAINING AZAHETEROCYCLES [J] . A. V. Velikorodov, V. B. Kovalev, O. V. Degtyarev, Pharmaceutical Chemistry Journal . 2011,第10期

机译：某些含氨基甲酸酯氮杂杂环化合物的合成及抗真菌活性
2. Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety. [J] . Lebouvier N, Pagniez F, Duflos M, Bioorganic and Medicinal Chemistry Letters . 2007,第13期

机译：具有氮杂杂环部分的新型氟康唑类似物的合成和抗真菌活性。
3. Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety. [J] . Lebouvier N, Pagniez F, Duflos M, Bioorganic and Medicinal Chemistry Letters . 2007,第13期

机译：具有氮杂杂环部分的新型氟康唑类似物的合成和抗真菌活性。
4. SYNTHESIS AND ANTIFUNGAL ACTIVITY EVALUATION OF NEW BENZIMIDAZOLE-TRIAZOLE DERIVATIVES AS POTENTIAL ERGESTEROL BIOSYNTHESIS INHIBITORS USING LC-MS/MS [C] . Nafiz Oncu Can, Ulviye Acar Cevik, Begum Nurpelin Saglik, International Mass Spectrometry Conference . 2018

机译：新型苯并咪唑 - 三唑衍生物作为使用LC-MS / MS的潜在伊代甲生物合成抑制剂的合成与抗真菌活性评价
5. Total synthesis and structure-activity relationship studies of antifungal peptidyl nucleoside antibiotics. [D] . Stauffer, Christina S. 2006

机译：抗真菌肽基核苷抗生素的全合成及其构效关系研究。
6. Synthesis Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone Hydrazone Derivatives as Potential Antifungal Agents [O] . Hao Wang, Shuang-Xi Ren, Ze-Yu He, 2014

机译：Carabrone Hydrazone衍生物作为潜在的抗真菌剂的合成抗真菌活性和定性结构活性关系
7. Synthesis, Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone Hydrazone Derivatives as Potential Antifungal Agents [O] . Hao Wang, Shuang-Xi Ren, Ze-Yu He, 2014

机译：Carabrone Hydrazone衍生物作为潜在抗真菌药物的合成，抗真菌活性和定性构效关系

SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME CARBAMATE-CONTAINING AZAHETEROCYCLES

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