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Indicatie voor therapeutic drug monitoring van mycofenolzuur

机译：霉酚酸治疗药物监测的适应症

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Reinier M. van Hest, Teun van Gelder, Ron A.A. Mathot Apotheek, Erasmus MC, Rotterdam. Abstract Indications for therapeutic drug monitoring of mycophenolate Mycophenolic acid (MPA) is the active component of the prodrugs mycophenolate mofetil and mycophenolate sodium. Exposure to MPA is highly variable and therefore therapeutic drug monitoring (TDM) of MPA is considered useful to optimize exposure to MPA and subsequently improve clinical outcome. This review aims at providing a practical overview of the current do's and don'ts for TDM of MPA. The pharmacokinetics of MPA, current dosing guidelines, target plasma concentrations of MPA and what to measure and how often when performing TDM of MPA are addressed. For renal transplant recipients, a TDM scheme for MPA consisting of four measurements of MPA exposure in the first month after transplantation is advised to reach and maintain target MPA AUC values of 30-60 mgl~(-1)h.
机译：Reinier M.van Hest，Teun van Gelder和Ron A.A. Mathot Apotheek，Erasmus MC，鹿特丹。摘要麦考酚酸酯治疗药物监测的适应症麦考酚酸（MPA）是前药麦考酚酸酯和麦考酚酸钠的活性成分。 MPA的暴露变化很大，因此MPA的治疗药物监测（TDM）被认为有助于优化MPA暴露并随后改善临床结局。本文旨在就MPA的TDM现行和不可行提供实用的概述。讨论了MPA的药代动力学，当前剂量指南，MPA的目标血浆浓度以及进行MPA的TDM时要测量的内容和频率。对于肾移植受者，建议在移植后的第一个月对MPA的TDM方案包括四次MPA暴露测量，以达到并维持目标MPA AUC值为30-60 mgl〜（-1）h。

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