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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Reinforcing effects of nicotinic compounds: intravenous self-administration in drug-naive mice.
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Reinforcing effects of nicotinic compounds: intravenous self-administration in drug-naive mice.

机译：烟碱类化合物的增强作用：未经药物治疗的小鼠的静脉内自我给药。

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摘要

The nicotinic compounds (-)-cytisine, (-)-lobeline, (+/-)-epibatidine, (S)-3methyl-5-(1-methyl-2-pyrrolidinyl)isoaxzole (ABT-418), (-)-nicotine, and cocaine were compared in an acute self-administration model using drug-naive mice that could self-administer intravenous infusions contingent on nose poking (fixed ratio 1 with no time out). Although the nose pokes of yoked control mice were unaffected by unit dose, inverted U-shaped unit dose response curves were seen with cocaine (up to 0.26 mg/kg/infusion), nicotine (up to 0.175 mg/kg/infusion), cytisine (up to 0.125 mg/kg/infusion), and lobeline (up to 1.25 mg/kg/infusion) in mice receiving infusions contingent upon nose poke responses. Epibatidine (up to 1.25 microg/kg/infusion) and ABT-418 (up to 0.125 mg/kg/infusion) failed to exhibit inverted U-shaped unit dose response curves. The present studies demonstrate that cytisine and lobeline, but not ABT-418 or epibatidine, were self-administered by drug-naive mice in a manner similar to cocaine and nicotine. These findings are discussed in terms of potency and selectivity at the alpha4beta2 nicotinic acetylcholine receptor subunit combination.
机译：烟碱类化合物（-）-胱氨酸，（-）-小叶碱，（+/-）-依巴替丁，（S）-3甲基-5-（1-甲基-2-吡咯烷基）异唑（ABT-418），（-） -尼古丁和可卡因在使用未经药物治疗的小鼠的急性自我给药模型中进行了比较，这些小鼠可以根据鼻子戳刺情况自动进行静脉输注（固定比率1，无超时）。尽管轭铁对照组小鼠的鼻po不受单位剂量的影响，但可卡因（最高至0.26 mg / kg /输注），尼古丁（最高至0.175 mg / kg /输注），半胱氨酸可观察到倒U型单位剂量反应曲线（最高0.125 mg / kg /滴注）和Lobeline（最高1.25 mg / kg /滴注）接受滴注的小鼠视鼻p反应而定。 Epibatidine（最高1.25 microg / kg /输液）和ABT-418（最高0.125 mg / kg /输液）未能显示出倒U型单位剂量反应曲线。本研究表明，初次使用药物的小鼠以类似于可卡因和尼古丁的方式自我施用了胱氨酸和卵磷脂，而非ABT-418或表巴替丁。这些发现将讨论在alpha4beta2烟碱乙酰胆碱受体亚基组合的效力和选择性方面。

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