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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behavioral pharmacology of zolpidem relative to benzodiazepines: a review.
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Behavioral pharmacology of zolpidem relative to benzodiazepines: a review.

机译：唑吡坦相对于苯二氮卓类药物的行为药理学：综述。

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Zolpidem, an imidazopyridine that purportedly binds selectively to certain GABA(A) receptor subtypes, is the most commonly prescribed hypnotic. The present article critically reviewed the extant experimental literature to determine whether the behavioral pharmacologic profile of zolpidem also differs from that of benzodiazepines. Specific topics that are reviewed include: 1) reinforcing effects and abuse potential, 2) discriminative-stimulus effects, 3) subject-rated drug effects, 4) performance-impairing effects, 5) tolerance-producing effects, and 6) physiological dependence-producing effects. Studies that employed both nonhumans and humans are reviewed. Based on the available literature, the most parsimonious conclusion is that despite its unique neuropharmacological profile, the behavioral effects of zolpidem are generally similar to those of benzodiazepines. However, it is important to note the dearth of perspective, experimental studies that directly compared zolpidem and a benzodiazepine. Because of the clinical relevance and paucity of published studies, future research should focus explicitly on assessing the reinforcing effects, abuse potential, performance-impairing effects, tolerance-producing effects, and dependence-producing effects of zolpidem relative to a benzodiazepine. Important issues such as the selection of an appropriate comparison drug and subject population, and the doses tested needed to be considered in these future studies.
机译：唑吡坦（一种据称与某些GABA（A）受体亚型选择性结合的咪唑并吡啶）是最常用的催眠药。本文严格审查了现有的实验文献，以确定唑吡坦的行为药理特征是否也不同于苯二氮卓类药物。所审查的具体主题包括：1）增强作用和滥用潜力，2）歧视性刺激作用，3）受受试者评定的药物作用，4）损害性能的作用，5）产生耐受性的作用，以及6）生理依赖性-产生影响。审查雇用非人类和人类的研究。根据现有文献，最简约的结论是，尽管唑吡坦具有独特的神经药理学特性，但其行为效应通常与苯并二氮杂卓相似。然而，重要的是要注意缺乏直接比较唑吡坦和苯并二氮杂experimental的实验研究的观点。由于已发表研究的临床相关性和缺乏性，未来的研究应明确集中于评估唑吡坦相对于苯二氮卓的增强作用，滥用潜力，性能损害作用，产生耐受性的作用和产生依赖性的作用。在这些未来的研究中，需要考虑重要的问题，例如选择合适的比较药物和对象人群，以及测试的剂量。

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