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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of food deprivation on conditioned taste aversions in rats.
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Effects of food deprivation on conditioned taste aversions in rats.

机译：食物匮乏对大鼠条件性味觉厌恶的影响。

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Food deprivation increases the rewarding effects of self-administered drugs such as psychomotor stimulants and benzodiazepines. These drugs also possess aversive properties and can produce conditioned taste aversions (CTA). Because drug-seeking behavior is most likely affected by both the rewarding and aversive properties of drugs, we hypothesize that food deprivation might also attenuate a drug's aversive consequences. The CTAs induced by three different drugs (amphetamine, chlordiazepoxide, and LiCl) were assessed separately. Male Long-Evans rats were assigned to one of two feeding conditions: restricted (maintained at 80% of free-feeding body weight), or nonrestricted (with ad lib food). Both groups received CTA training, consisting of an intraoral infusion of a novel saccharin solution (10 min) followed immediately by one of two i.p. injections: paired rats received drug, and unpaired rats received a similar volume of saline. After 10 days of ad lib food access, saccharin was presented to all rats again, and the latency to reject the tastant was used as an index of CTA learning. The rats that had been food restricted at the time of conditioning exhibited attenuated CTAs relative to those that had not been deprived. These differences were seen only when a rewarding drug (amphetamine or chlordiazepoxide) and not when a nonrewarding drug (LiCl) was used as the unconditioned stimulus. In a separate experiment, we established that this effect is apparent only when the deprivation period precedes conditioning rather than precedes testing. The present results indicate that food deprivation modulates the acquisition of a CTA induced by amphetamine or chlordiazepoxide, but not LiCl.
机译：食物匮乏增加了诸如精神运动兴奋剂和苯二氮卓类药物等自用药物的奖励作用。这些药物还具有厌恶性，可以产生条件性味觉厌恶（CTA）。因为寻求毒品的行为很可能同时受到毒品的奖励和厌恶特性的影响，所以我们假设食物匮乏也可能削弱毒品的厌恶后果。分别评估了三种不同药物（苯丙胺，氯二氮卓和LiCl）诱导的CTAs。将雄性Long-Evans大鼠指定为以下两种喂养条件之一：限制（保持自由喂养体重的80％）或非限制（自由进食）。两组均接受了CTA培训，包括口服新糖精溶液（10分钟），然后立即接受两个腹膜内注射之一。注射：成对的大鼠接受药物治疗，而未成对的大鼠接受相似体积的生理盐水。随意进食10天后，将糖精再次提供给所有大鼠，并将拒绝促味剂的潜伏期用作CTA学习的指标。与未剥夺的大鼠相比，在调理时受到食物限制的大鼠的CTAs减弱。仅当使用奖励药物（安非他明或氯二氮卓）时才看到这些差异，而当使用无奖励药物（LiCl）作为无条件刺激时则看不到这些差异。在一个单独的实验中，我们确定只有当剥夺期在调节之前而不是测试之前，这种影响才明显。目前的结果表明，食物匮乏会调节苯丙胺或氯二氮卓而不是LiCl诱导的CTA的获取。

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