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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Beneficial effects of acute and repeated administrations of sigma receptor agonists on behavioral despair in mice exposed to tail suspension.
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Beneficial effects of acute and repeated administrations of sigma receptor agonists on behavioral despair in mice exposed to tail suspension.

机译：急性和反复施用sigma受体激动剂对暴露于尾巴悬吊的小鼠的行为绝望的有益影响。

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In an attempt to examine whether sigma receptor agonists alleviate behavioral despair, we investigated the effects of sigma receptor agonists on the tail suspension-induced immobility in mice. The acute and repeated (14 days) administrations of sigma1 receptor agonists, such as 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) (1 and/or 3 mg/kg) and (+)-pentazocine (5.6 mg/kg), sigma1/2 receptor agonists, such as 1,3-di(2-tolyl)guanidine (DTG) (3 and/or 5.6 mg/kg), desipramine (7.5 and/or 15 mg/kg), and fluoxetine (10 and/or 20 mg/kg), reduced immobility in mice exposed to tail suspension. N,N-Dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine monohydrochloride (NE-100), a sigma1 receptor antagonist, significantly antagonized the decrease in immobility induced by acute administrations of SA4503 (1 mg/kg) and (+)-pentazocine (5.6 mg/kg). Although not significant, NE-100 showed a tendency to inhibit the DTG (5.6 mg/kg)-induced decrease in immobility. In contrast, repeated administrations of SA4503 (1 and 3 mg/kg), (+)-pentazocine (5.6 mg/kg) or DTG (5.6 mg/kg) failed to affect the increase in body weight. These results suggest that acute and repeated stimulations of sigma, possibly a sigma1 receptor subtype, alleviate behavioral despair, unaccompanied with changes in body weight.
机译：为了尝试检查sigma受体激动剂是否缓解行为绝望，我们研究了sigma受体激动剂对小鼠尾部悬吊诱导的不动的影响。急性和反复（14天）施用sigma1受体激动剂，例如1-（3,4-二甲氧基苯乙基）-4-（3-苯基丙基）哌嗪二盐酸盐（SA4503）（1和/或3 mg / kg）和（ +）-喷他佐辛（5.6 mg / kg），sigma1 / 2受体激动剂，例如1,3-二（2-甲苯基）胍（DTG）（3和/或5.6 mg / kg），地昔帕明（7.5和/或15毫克/千克）和氟西汀（10和/或20毫克/千克）减少了暴露于尾部悬架的小鼠的固定能力。 sigma1受体拮抗剂N，N-二丙基-2- [4-甲氧基-3-（2-苯基乙氧基）苯基]乙胺盐酸盐（NE-100）显着拮抗急性给予SA4503（1 mg / kg）和（+）-戊唑嗪（5.6 mg / kg）。尽管不显着，但NE-100表现出抑制DTG（5.6 mg / kg）引起的运动性下降的趋势。相反，重复施用SA4503（1和3 mg / kg），（+）-戊唑嗪（5.6 mg / kg）或DTG（5.6 mg / kg）无法影响体重的增加。这些结果表明，对sigma（可能是sigma1受体亚型）的急性和反复刺激，可以减轻行为上的绝望，而无需伴随体重的变化。

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